Friday, July 4, 2025 7/4/2025

Development of an immunomodulating peptide as a therapy for osteosarcoma in canine and human

Award Number: R44CA278570
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/19/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2025

Group Awards By:

View Award Description

Development of an immunomodulating peptide as a therapy for osteosarcoma in canine and human - Osteosarcoma (OSA) is the most common primary malignancy of bone in children and adolescents, accounting for approximately 5% of all childhood tumors (www.cancer.gov). Osteosarcoma occurs primarily in the long bones of the limbs, including most commonly the femur, tibia, and humerus1. The current standard of care therapy for human patients diagnosed with OSA includes multi-agent neoadjuvant chemotherapy (doxorubicin + cisplatin +/- methotrexate) followed by surgical resection of the primary lesion and adjuvant chemotherapy, curing approximately 60 to 70% of patients 1–3. However, up to 40% of newly diagnosed patients presenting with localized disease eventually develop metastases to the lung, indicating that many patients already have micrometastases present in the lung at the time of diagnosis or develop them during the perioperative period 4. The 5-year survival rate for children with metastatic OSA is extremely low, hovering around 20%-30%, a rate that has not improved in over 30 years 2. Clearly, novel therapies are in critical need, specifically molecules capable of inhibiting the process of OSA metastasis. PharmaIN is developing immunomodulating peptide with unique anti-tumor and anti-fibrotic properties for the treatment of osteosarcoma and other cancer types. The peptide’s anti-tumor activity has been demonstrated as a monotherapy and combination with other immuno/chemotherapies in multiple cancer models, including OSA metastatic model. Pilot tox data has been obtained and PharmaIN proposes to conduct a clinical trial in canine OSA patients as a translation tool for human and concurrent product development for veterinary applications. The additional proposed work is IND enabling for a Phase 1 human clinical trial and consists of manufacturing drug substance and drug product needed for GLP-tox and clinical studies, completion of GLP-tox studies and submission of the IND for the OSA indication.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $995,099 )
2024	2024	PHARMAIN CORPORATION	11812 N CREEK PKWY N STE 101	BOTHELL	WA	98011	KING	USA	Cancer Treatment Research	000	2	8/16/2024	NON-COMPETING CONTINUATION	$995,099
														Subtotal = $995,099

Issue Date FY: 2023 ( Subtotal = $995,100 )
2023	2023	PHARMAIN CORPORATION	11812 N CREEK PARKWAY N STE 101	BOTHELL	WA	98011	KING	USA	Cancer Treatment Research	000	1	9/19/2023	NEW	$995,100
														Subtotal = $995,100

Grand Total All Awards = $1,990,199

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Development of an immunomodulating peptide as a therapy for osteosarcoma in canine and human

Award Number: R44CA278570

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/19/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer