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Multiplexed detection and imaging of protein phosphorylation based on soluble nanopolymers

Award Number: R44CA200040
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2015
PERIOD OF PERFORMANCE END DATE: 06/30/2019

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Multiplexed detection and imaging of protein phosphorylation based on soluble nanopolymers - ¿ DESCRIPTION (provided by applicant): With recent technical advances, multiple important signaling pathways that may be the causes of human malignancy have continuously been discovered and dissected. The vast majority of these signaling pathways involve reversible protein phosphorylation, and the information on the location and dynamics of phosphorylation provides important mechanisms on how the signaling networks function and interact. While translational research gradually shifts from lab models to clinical samples, with the ultimate goal of identifying cancer biomarkers, a simple and reliable phosphorylation assay method is still missing for routine detection of phosphorylation in complex and typically heterogeneous clinical samples. Through this NIH SBIR Phase II study we will further develop a novel strategy for phosphorylation assay, termed pIMAGO (phospho-imaging), which has recently been introduced and commercialized by us, into highly effective products for simple and routine phosphorylation assays. This novel design takes advantage of not only the quantum size properties of the soluble nanoparticles, but also of the multi-functionalized nature of the molecule, allowing for highly selective, sensitive and simple qualitative and quantitative assessment of protein phosphorylation without the use of either radioactive isotopes or expensive phosphospecific antibodies. Due to its size and unique properties, it also offers the capability for multiplexed detection of phosphorylation and total protein amount simultaneously. We propose to optimize the technology for universal on-membrane phosphoprotein detection in routine biological and biomedical research. In addition, we will develop a set of novel pIMAGO-based strategies for multiplexed detection of phosphorylation in antibody microarray and functional reversed phase array formats. The new applications will add another dimension to traditional biomedical research and development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2016	TYMORA ANALYTICAL OPERATIONS, LLC	1201 CUMBERLAND AVE STE 209	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Cancer Biology Research	000	3	8/28/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	TYMORA ANALYTICAL OPERATIONS, LLC	3495 KENT AVE STE E400	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Cancer Biology Research	000	3	7/13/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $445,595 )
2016	2016	TYMORA ANALYTICAL OPERATIONS LLC	1281 WIN HENTSCHEL BOULEVARD	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Cancer Biology Research	000	3	7/25/2016	NON-COMPETING CONTINUATION	$445,595
														Subtotal = $445,595

Issue Date FY: 2015 ( Subtotal = $451,538 )
2015	2015	TYMORA ANALYTICAL OPERATIONS LLC	1281 WIN HENTSCHEL BOULEVARD	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Cancer Biology Research	000	2	7/1/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$451,538
														Subtotal = $451,538

Grand Total All Awards = $897,133

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Multiplexed detection and imaging of protein phosphorylation based on soluble nanopolymers

Award Number: R44CA200040

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2015

PERIOD OF PERFORMANCE END DATE: 06/30/2019

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