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Optical imaging for radiation therapy dose verification on patients

Award Number: R44CA199836
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2015
PERIOD OF PERFORMANCE END DATE: 08/31/2017

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Optical imaging for radiation therapy dose verification on patients - ¿ DESCRIPTION (provided by applicant): For the first time, it is possible to directly visualize a radiation beam incident upon a patient's tissue in real time, using Cerenkov emission imaging. This imaging could transform the ease for verifying delivery in radiation oncology, and allow on the fly reporting, recording and correction of replanning needs or delivery errors. In a field wher there is an incredibly high number of new technologies for delivery, the verification of delivery and recording of adverse incidents will become more and more critical and yet the ease of implementation must be improved. A recent discovery that gated intensified imaging allows video-rate passive detection of Cherenkov emission during radiation therapy with the room lights on, and so the delivery process is unaffected by the imaging system. This opens up a new important paradigm in radiation oncology verification. This work has been invented and patented at Dartmouth, and DoseOptics LLC is a company spin-off of this research program, with the goal to advance video-rate Cerenkov imaging as a dose delivery visualization & verification tool. The feasibility of the system has been proven through the technological refinement and pilot clinical trial at Dartmouth. The next phase of this work involves the DoseOptics prototype development as a C-Dose OnBoard verification tool for imaging patients during treatment from the view of the LINAC gantry. The system will be developed with a unique proprietary moderate cost design, which will then be tested in phantoms and with patient treatment plans delivered to water tanks. The system will have capabilities for video-rate capture of IMRT/VMAT data, tracking MLC movements in real time, and allowing analysis of treatment plans on a beam to beam basis. The competing technologies using ionization chambers or diode arrays are low resolution devices with limitations that they cannot eventually translate to direct on-patient imaging. The work carried out in the company is augmented by a plan to evaluate the system in Clinical Physics at Dartmouth, and be further evaluated at Stanford and UPenn. The technology patent protected as developed by this group, and for this start up, the team of developers includes a substantial number of experts in Cerenkov imaging, medical physics and new venture creation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	DOSEOPTICS LLC	16 CAVENDISH CT	LEBANON	NH	03766	GRAFTON	USA	Cancer Treatment Research	000	2	2/20/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $571,718 )
2016	2016	DOSEOPTICS LLC	7 HEMLOCK RD	HANOVER	NH	03755	GRAFTON	USA	Cancer Treatment Research	000	2	8/5/2016	NON-COMPETING CONTINUATION	$571,718
														Subtotal = $571,718

Issue Date FY: 2015 ( Subtotal = $715,463 )
2015	2015	DOSEOPTICS LLC	7 HEMLOCK RD	HANOVER	NH	03755	GRAFTON	USA	Cancer Treatment Research	000	1	8/26/2015	NEW	$715,463
														Subtotal = $715,463

Grand Total All Awards = $1,287,181

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Optical imaging for radiation therapy dose verification on patients

Award Number: R44CA199836

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2015

PERIOD OF PERFORMANCE END DATE: 08/31/2017

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