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Dual Mode Hand Held Intraoperative Imager

Award Number: R44CA168100
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/26/2012
PERIOD OF PERFORMANCE END DATE: 11/30/2019

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Dual Mode Hand Held Intraoperative Imager - Radionuclide-guided intraoperative probes increase the specificity of tissue biopsies, enable minimal- access incisions, reduce inpatient hospital utilization, and contribute to improved patient recovery. At present, most such probes on the market are non-imaging, and provide no ancillary information of surveyed areas, such as clear delineations of malignant tissues. Our goal is to develop a revolutionary new imaging probe, the Imaging Beta Probe™ (IBP™), intended for rapid localization of lesions by sensing gamma rays, followed by real-time high-sensitivity imaging of short-range beta particles or positrons. This ergonomically designed probe will be small and easy to use during surgery, and is made possible by the recent development of solid-state photomultipliers and hybrid scintillation technologies at RMD. The probe will provide continuous real-time audio and/or video feedback of emissions from surveyed areas to the surgeon for rapid and accurate delineation and precise excision of lesions, with minimal sacrifice of surrounding healthy tissue. After excision of suspect tissue, the IBP™ will allow the surgeon to check the tumor bed and margins for any remaining cancerous and pre- cancerous tissue, fine tumors or other tissues (e.g., endometrial) capable of uptake of the administered tracer, that are otherwise obscured by background radiation. Our motivation in pursuing the proposed Imaging Beta Probe design is that it will provide the first radical change in probe technology in decades and, most importantly, significant improvement in and broadening of the clinical capabilities of intraoperative and external diagnostic probes. Development of this technology will provide an imaging tool for surgeons to detect PET-positive lesions intra-operatively, which will advance their ability to confirm data provided by PET scans with biopsy material. Furthermore, these tools may allow a surgeon to perform a PET-guided exploration and therapeutic excision of a small lesion that would otherwise be undiscovered by conventional exploration or treated by a harsh empiric regimen of chemotherapy or radiation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$3,582 )
2023	2018	RADIATION MONITORING DEVICES, INC.	44 HUNT ST	WATERTOWN	MA	02472	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	000	4	2/2/2023	NON-COMPETING CONTINUATION	-$3,582
														Subtotal = -$3,582

Issue Date FY: 2020 ( Subtotal = -$1,795 )
2020	2018	RADIATION MONITORING DEVICES, INC.	44 HUNT ST #2	WATERTOWN	MA	02472	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	000	4	6/15/2020	NON-COMPETING CONTINUATION	-$1,795
														Subtotal = -$1,795

Issue Date FY: 2018 ( Subtotal = $662,164 )
2018	2018	RADIATION MONITORING DEVICES, INC.	44 HUNT ST #2	WATERTOWN	MA	02472	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	000	4	5/25/2018	NON-COMPETING CONTINUATION	$662,164
														Subtotal = $662,164

Issue Date FY: 2017 ( Subtotal = $689,590 )
2017	2017	RADIATION MONITORING DEVICES, INC.	44 HUNT ST #2	WATERTOWN	MA	02472	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	001	3	4/20/2017	COMPETING CONTINUATION	$61,621
2017	2017	RADIATION MONITORING DEVICES, INC.	44 HUNT ST #2	WATERTOWN	MA	02472	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	000	3	3/30/2017	COMPETING CONTINUATION	$627,969
														Subtotal = $689,590

Grand Total All Awards = $1,346,377

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Dual Mode Hand Held Intraoperative Imager

Award Number: R44CA168100

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/26/2012

PERIOD OF PERFORMANCE END DATE: 11/30/2019

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