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FAST ACOUSTO-OPTIC TOMOGRAPHY SYSTEM

Award Number: R44CA137879
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/26/2008
PERIOD OF PERFORMANCE END DATE: 05/31/2014

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FAST ACOUSTO-OPTIC TOMOGRAPHY SYSTEM - DESCRIPTION (provided by applicant): To improve the probability of earlier breast cancer detection while reducing the number of unnecessary needle biopsies, Physical Optics Corporation proposes to develop a new Fast Acousto-Optic Tomography System (FAOTS) as an auxiliary tool for the conventional ultrasound breast examination that often follows a screening mammography. The innovative FAOTS will provide images with better contrast than sonography, because the optical properties of normal tissue and tissue with neoplasia differ much more than their acoustic properties. FAOTS will use a tightly focused ultrasound beam to shift the frequency of photons at a certain location in a tissue and detect them using a heterodyne technique utilizing a parallel signal acquisition by multiple photodetectors on a fast CMOS chip. The utilization of a high-speed (>4000 fps) CMOS camera with a large memory capacity enables signal detection in a short time interval, so speckle decorrelation in the live tissue will not affect system operation. In Phase I, POC experimentally demonstrated the capability of the laboratory prototype of obtaining high contrast signals with a speed exceeding the speckle decorrelation time. In Phase II, POC will design and fabricate an engineering FAOTS prototype and conduct a demonstration of its capability of mapping the optical properties of patient breast tissue at Harbor-UCLA Medical Center in Torrance, California. The fully developed FAOTS will provide a spatial resolution of ~0.4 mm, which is significantly better than Optical Diffuse Tomography (ODT). The FAOTS technology will enable positive predictive value (PPV) improvement in breast cancer diagnostics, with earlier detection of smaller tumors, thus enhancing patients' chances for long-time survival after cancer treatment. The successful demonstration of the FAOTS technology for mapping the optical properties of breast tissue will broaden the perspective for the extension of the FAOTS technology using multiple light wavelengths for improving image contrast. It will also facilitate development of special instrumentation for mapping the optical properties of other internal organs, and better diagnostics of tumors in these organs (e.g., prostate).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2011	PHYSICAL OPTICS CORPORATION	20600 GRAMERCY PL, #103	TORRANCE	CA	90501	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	000	3	7/18/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $1,010,121 )
2011	2011	PHYSICAL OPTICS CORPORATION	20600 GRAMERCY PL, #103	TORRANCE	CA	90501	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	000	3	5/31/2011	NON-COMPETING CONTINUATION	$1,010,121
														Subtotal = $1,010,121

Issue Date FY: 2010 ( Subtotal = $998,456 )
2010	2010	PHYSICAL OPTICS CORPORATION	20600 GRAMERCY PL, #103	TORRANCE	CA	90501	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	000	2	5/17/2010	COMPETING CONTINUATION	$1,169,121
2010	2010	PHYSICAL OPTICS CORPORATION	20600 GRAMERCY PL, #103	TORRANCE	CA	90501	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	001	2	5/31/2010	COMPETING CONTINUATION	-$170,665
														Subtotal = $998,456

Grand Total All Awards = $2,008,577

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FAST ACOUSTO-OPTIC TOMOGRAPHY SYSTEM

Award Number: R44CA137879

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/26/2008

PERIOD OF PERFORMANCE END DATE: 05/31/2014

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