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Quantitative, Image-Based Osteoarthritis Biomarkers Software Resubmission

Award Number: R44AR074375
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2023

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Quantitative, Image-Based Osteoarthritis Biomarkers Software Resubmission - PROJECT SUMMARY Musculoskeletal diseases are common in the United States, especially among the elderly and individuals of low socioeconomic status, and they take a large toll on the Nation's overall health status. Bone disorders are diagnosed by exploring a patient's medical history and by physical exam, alongside laboratory tests, bone biopsies, and imaging tests. Bone imaging tests provide a non-invasive way to examine at bone structure. However, imaging data is often evaluated qualitatively or with operator dependence as opposed to automated or quantitative measurements. These quantitative measurements are not sensitive enough to detect subtle variations in bone quality associated with early disease progression. We propose the development of high performance, multimodal, and automated 3D bone characterization tools, which are accessible through a web browser. A broad range of researchers and clinicians can leverage these tools to obtain high-throughput, reproducible biomarkers for statistically sensitive research studies. The system will automatically segment bone and cartilage and quantify biomarkers from the regions of interest. The proposed system will have superior high-throughput capabilities over existing bone image analysis suites, and it will provide access to state-of-the-art algorithms for researchers without programming abilities. In addition to providing a powerful resource to the research community, we will commercialize this complete, streamlined analytical solution by offering it as an online fee-per-image processing service. Our system will be validated by demonstrating that we can detect skeletal deterioration in preclinical studies, which can potentially lead to new clinical trials for novel therapeutic and diagnostic approaches in humans. We will test the hypothesis that the system can automatically identify osteoarthritis in knee images from the Osteoarthritis Initiative database and differentiate hemophilia in micro-computed tomography images. The ultimate goal of the proposed project is to lead to better preventive strategies and improved progression monitoring of osteoarthritis and related diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$5,170 )
2024	2021	KITWARE INC	1712 ROUTE 9	HALFMOON	NY	12065	SARATOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	3/17/2024	NON-COMPETING CONTINUATION	-$5,170
														Subtotal = -$5,170

Issue Date FY: 2021 ( Subtotal = $445,896 )
2021	2021	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	3	8/26/2021	NON-COMPETING CONTINUATION	$445,896
2021	2020	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	2	2/5/2021	EXTENSION WITH OR WITHOUT FUNDS	$102
2021	2019	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	2/5/2021	NEW	-$102
														Subtotal = $445,896

Issue Date FY: 2020 ( Subtotal = $449,999 )
2020	2020	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	8/31/2020	EXTENSION WITH OR WITHOUT FUNDS	$449,999
2020	2019	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	9/18/2020	NEW	$0
														Subtotal = $449,999

Issue Date FY: 2019 ( Subtotal = $100,530 )
2019	2019	KITWARE, INC.	1712 ROUTE 9 STE 300	CLIFTON PARK	NY	12065	SARATOGA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	8/29/2019	NEW	$100,530
														Subtotal = $100,530

Grand Total All Awards = $991,255

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Quantitative, Image-Based Osteoarthritis Biomarkers Software Resubmission

Award Number: R44AR074375

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2023

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