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Stem cell-binding peptides for rapid fixation of total hip replacements

Award Number: R44AR066997
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2014
PERIOD OF PERFORMANCE END DATE: 07/31/2021

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Stem cell-binding peptides for rapid fixation of total hip replacements - SUMMARY/ABSTRACT Through modern surgical advancements, total hip replacements (THR) have become one of the most successful implant procedures to date. Even though long-term success rates are high, the staggering number of THR procedures performed (~365,000 per year in the United States alone) results in thousands of failed implants each year. Most implants fail through aseptic loosening and implant instability. Earlier implant designs utilized various types of synthetic bone cement, all of which elicited localized inflammatory responses and stimulated bone resorption. In response, physicians shifted towards cementless, porous-coated implants and this implant design is now used in a majority of THR procedures. However, effective and rapid fixation is critical to both the short- and long-term success of hip implants, especially given the increasingly young and active patient populations opting for THR. Thus, the need exists for improved hip implant design to facilitate rapid implant fixation in active and mobile patients. Unlike cemented implants, cementless implants achieve fixation by press-fitting surface-modified titanium into bone that eventually allows ingrowth. Due to the nature of these implants, adequate bone ingrowth is critical for patient recovery. Materials such as hydroxyapatite hasten bone ingrowth, but these coatings may promote osteolysis due to wear particles from degradation. As an alternative, bone marrow-derived mesenchymal stem cells (BMSCs) may be used as a treatment to promote bone formation. Current methods utilize ex vivo BMSC culture. This creates several practical and regulatory challenges. As an alternative, we have developed peptides that bind BMSCs with high specificity and affinity. Our goal is to attach these peptides onto the surface of the femoral components of hip implants to capture BMSCs from the implant’s marrow-rich surroundings onto the implant surface. In preliminary studies, we have demonstrated that mineralization in stem cell cultures is dependent upon cell concentration. Thus, we hypothesize that concentrating BMSCs on titanium implants will speed the patient recovery process and improve short-term clinical outcomes for cementless implants.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2018	AFFINERGY, LLC	104 TW ALEXANDER DRIVE, BLDG. 20	DURHAM	NC	27709	DURHAM	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	12/22/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	AFFINERGY, LLC	601 KEYSTONE PARK DR STE 100	MORRISVILLE	NC	27560	WAKE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	6/22/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $746,272 )
2018	2018	AFFINERGY, LLC	601 KEYSTONE PARK DR STE 100	MORRISVILLE	NC	27560	WAKE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	7/18/2018	NON-COMPETING CONTINUATION	$746,272
														Subtotal = $746,272

Issue Date FY: 2017 ( Subtotal = $749,918 )
2017	2017	AFFINERGY, LLC	601 KEYSTONE PARK DR STE 100	MORRISVILLE	NC	27560	WAKE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	8/2/2017	COMPETING CONTINUATION	$749,918
														Subtotal = $749,918

Grand Total All Awards = $1,496,190

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Stem cell-binding peptides for rapid fixation of total hip replacements

Award Number: R44AR066997

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2014

PERIOD OF PERFORMANCE END DATE: 07/31/2021

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