Thursday, June 19, 2025 6/19/2025

Multivalent Conjugates of Sonic Hedgehog to Accelerate Diabetic Wound Healing

Award Number: R44AR062418
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2012
PERIOD OF PERFORMANCE END DATE: 01/31/2018

Group Awards By:

View Award Description

Multivalent Conjugates of Sonic Hedgehog to Accelerate Diabetic Wound Healing - DESCRIPTION: In 2012, nearly one million Americans with diabetes were diagnosed with a lower extremity ulcer, and failure of these wounds to heal resulted in more than 75,000 lower extremity amputations. Valitor, Inc. is developing protein-polymer therapeutics to overcome the micro vascular consequences of diabetic wound healing. We designed our therapy to complement the standard practice of diabetic ulcer management and to reduce the costly serial effort required for debridement and clinical observation of these slowly healing wounds. Our patented technology is a bio conjugation process that enables us tether Sonic hedgehog (Shh), an important angiogenic factor, to linear chains of hyaluronic acid (HyA) at defined Shh:HyA ratios (i.e., valency). In Phase I of this project, we verified that Shh valency correlated with enhanced Shh-induced cellular functions, including downstream angiogenic signaling, which were substantially unregulated relative to equimolar concentrations of unconjugated Shh. We further demonstrated that after treatment with multivalent Shh conjugates (mvShh), full- thickness excisional wounds in db/db diabetic mice exhibited significantly greater neovascular density and faster closure times compared to wounds treated with unconjugated Shh or vehicle controls. Our overall goal during Phase II is to build on these promising proof-of-mechanism results by completing the lead optimization process and to advance mvShh to as a candidate for pre-clinical studies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = -$138,933 )
2018	2015	VALITOR, INC.	820 HEINZ AVE	BERKELEY	CA	94710	ALAMEDA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	6/5/2018	NON-COMPETING CONTINUATION	-$138,933
														Subtotal = -$138,933

Issue Date FY: 2017 ( Subtotal = $1,653 )
2017	2015	VALITOR, INC.	820 HEINZ AVE	BERKELEY	CA	94710	ALAMEDA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	3	3/27/2017	NON-COMPETING CONTINUATION	$0
2017	2014	VALITOR, INC.	820 HEINZ AVE	BERKELEY	CA	94710	ALAMEDA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	1/14/2017	COMPETING CONTINUATION	$1,653
														Subtotal = $1,653

Issue Date FY: 2015 ( Subtotal = $782,937 )
2015	2015	VALITOR INC	3841 COMPOLINDO DRIVE	MORAGA	CA	94556	CONTRA COSTA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	4/28/2015	NON-COMPETING CONTINUATION	$782,937
														Subtotal = $782,937

Issue Date FY: 2014 ( Subtotal = $716,719 )
2014	2014	VALITOR INC	3841 COMPOLINDO DRIVE	MORAGA	CA	94556	CONTRA COSTA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	5/1/2014	COMPETING CONTINUATION	$716,719
														Subtotal = $716,719

Grand Total All Awards = $1,362,376

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Multivalent Conjugates of Sonic Hedgehog to Accelerate Diabetic Wound Healing

Award Number: R44AR062418

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2012

PERIOD OF PERFORMANCE END DATE: 01/31/2018

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer