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A Topical Non-steroidal Anti-inflammatory for Atopic Dermatitis

Award Number: R44AR058020
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2010
PERIOD OF PERFORMANCE END DATE: 05/31/2017

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A Topical Non-steroidal Anti-inflammatory for Atopic Dermatitis - DESCRIPTION (provided by applicant): Atopic dermatitis is a chronic dermatological condition afflicting mostly infants and young children. Current treatments are associated with a wide range of side effects therefore development of novel therapeutic agents that are efficacious and have an improved safety profile is needed. Although disease etiology has yet to be fully understood, skin inflammation is known to be critically involved in the disease pathology. Signum has identified novel potent topical anti-inflammatory agents called isoprenylcysteines (IPCs) with no detectable adverse affects. The proposed Phase II research plan will identify one lead compound and one backup for preclinical development and will establish the analytical methods, process development and formulation necessary to conduct IND-enabling studies (e.g. pharmacokinetic, toxicology and safety pharmacology determination). Together, the data generated from these studies will allow Signum to prepare and submit an IND for treatment of atopic dermatitis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2014	SIGNUM BIOSCIENCES, INC.	11 DEERPARK DR STE 202	MONMOUTH JUNCTION	NJ	08852	MIDDLESEX	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	2/11/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2014	SIGNUM BIOSCIENCES INC	1 DEER PARK DRIVE	MONMOUTH JUNCTION	NJ	08852	MIDDLESEX	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	6/22/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $676,059 )
2014	2014	SIGNUM BIOSCIENCES INC	1 DEER PARK DRIVE	MONMOUTH JUNCTION	NJ	08852	MIDDLESEX	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	8/26/2014	NON-COMPETING CONTINUATION	$676,059
														Subtotal = $676,059

Issue Date FY: 2013 ( Subtotal = $998,971 )
2013	2013	SIGNUM BIOSCIENCES INC	1 DEER PARK DRIVE	MONMOUTH JUNCTION	NJ	08852	MIDDLESEX	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	9/19/2013	COMPETING CONTINUATION	$998,971
														Subtotal = $998,971

Grand Total All Awards = $1,675,030

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A Topical Non-steroidal Anti-inflammatory for Atopic Dermatitis

Award Number: R44AR058020

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2010

PERIOD OF PERFORMANCE END DATE: 05/31/2017

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