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Live Cell Fluorescent Assays for SARS-CoV-2 protease activity and COVID-19 Drug Discovery

Award Number: R44AI165188
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/13/2022
PERIOD OF PERFORMANCE END DATE: 10/31/2024

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Live Cell Fluorescent Assays for SARS-CoV-2 protease activity and COVID-19 Drug Discovery - SUMMARY STATEMENT The SARS-CoV-2 virus depends upon two proteases for replication, 3CLpro and PLpro. If one or both of these proteases can be blocked, COVID-19 infection can be effectively treated. Montana Molecular makes and sells live cell, fluorescent biosensor assays for disease research and drug discovery. In response to the COVID-19 pandemic, Montana Molecular applied its expertise and background in live cell assay development to build fluorescent biosensors for the SARS-CoV-2 main protease, 3CLpro. The prototype sensor described in this proposal demonstrates feasibility. Direct to Phase II support is requested here to speed the development of even brighter, more sensitive assays for the 3CLpro and PLpro proteases. These assays can be used in high throughput screening for compounds that inhibit the protease, and engage with their target in living, human cells. 406-539-7399 366 Gallatin Park Drive Suite A Bozeman, MT 59715


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	MONTANA MOLECULAR LLC	366 GALLATIN PARK DR STE A	BOZEMAN	MT	59715	GALLATIN	USA	Allergy and Infectious Diseases Research	000	2	4/23/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $300,000 )
2023	2023	MONTANA MOLECULAR LLC	366 GALLATIN PARK DR	BOZEMAN	MT	59715	GALLATIN	USA	Allergy and Infectious Diseases Research	000	2	5/23/2023	NON-COMPETING CONTINUATION	$300,000
														Subtotal = $300,000

Issue Date FY: 2022 ( Subtotal = $300,000 )
2022	2022	MONTANA MOLECULAR LLC	366 GALLATIN PARK DR STE A	BOZEMAN	MT	59715	GALLATIN	USA	Allergy and Infectious Diseases Research	000	1	5/13/2022	NEW	$300,000
														Subtotal = $300,000

Grand Total All Awards = $600,000

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Live Cell Fluorescent Assays for SARS-CoV-2 protease activity and COVID-19 Drug Discovery

Award Number: R44AI165188

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/13/2022

PERIOD OF PERFORMANCE END DATE: 10/31/2024

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