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Rapid Point-of-Care RNA Diagnostic for Dengue Infection

Award Number: R44AI140813
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2019
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Rapid Point-of-Care RNA Diagnostic for Dengue Infection - Abstract Rapid Point-of-Care RNA Diagnostic for Dengue Infection CrossLife Technologies Inc. Project Summary/Abstract Dengue viruses (DENV) are one of the most dangerous and significant pathogens in the world, and there are 230 million cases of dengue virus infections per year, mostly in Latin America and Southeast Asia. These mosquito-borne viruses cause periodic explosive epidemics in many tropical and sub-tropical countries. CrossLife technologies' dengue diagnostic is being developed to detect dengue infection early at the point-of-care so that patients can be treated effectively. Early and rapid detection of dengue virus (DENV) infection during the febrile period is crucial for proper patient management and containment of the disease. However, current methods for early detection of dengue involve the use of RT-PCR instruments in the laboratory, which may not be available in areas where dengue is endemic, and which may be too slow. CrossLife Technologies proposed to develop a Template Assisted Rapid Assay (TARA) diagnostics for detection of dengue viruses in human blood. TARA dengue diagnostic will detect dengue in 30 minutes on a paper strip at the point-of-care (POC) so that patients can be treated rapidly and at low cost. This innovative technology will provide PCR-less, instrumentation-free, low-cost, disposable, rapid and sensitive POC dengue diagnostics directly from whole blood samples.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2022	CROSSLIFE TECHNOLOGIES INC.	5937 DARWIN CT	CARLSBAD	CA	92008	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	3	1/22/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	CROSSLIFE TECHNOLOGIES INC.	5937 DARWIN CT	CARLSBAD	CA	92008	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	3	8/19/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $999,799 )
2022	2022	CROSSLIFE TECHNOLOGIES INC.	5937 DARWIN COURT, #105	CARLSBAD	CA	92008	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	3	8/3/2022	NON-COMPETING CONTINUATION	$999,799
2022	2019	CROSSLIFE TECHNOLOGIES INC.	5937 DARWIN COURT, #105	CARLSBAD	CA	92008	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	1	2/1/2022	NEW	$0
														Subtotal = $999,799

Issue Date FY: 2021 ( Subtotal = $999,799 )
2021	2021	CROSSLIFE TECHNOLOGIES INC.	5937 DARWIN COURT, #105	CARLSBAD	CA	92008	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	2	8/13/2021	EXTENSION WITH OR WITHOUT FUNDS	$999,799
2021	2019	CROSSLIFE TECHNOLOGIES INC.	5937 DARWIN COURT, #105	CARLSBAD	CA	92008	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	1	2/5/2021	NEW	$0
														Subtotal = $999,799

Issue Date FY: 2019 ( Subtotal = $299,410 )
2019	2019	CROSSLIFE TECHNOLOGIES INC.	5937 DARWIN COURT, #105	CARLSBAD	CA	92008	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	1	3/14/2019	NEW	$254,470
2019	2019	CROSSLIFE TECHNOLOGIES INC.	5937 DARWIN COURT, #105	CARLSBAD	CA	92008	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	1	3/18/2019	NEW	$44,940
2019	2019	CROSSLIFE TECHNOLOGIES INC.	5937 DARWIN COURT, #105	CARLSBAD	CA	92008	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	1	9/12/2019	NEW	$0
														Subtotal = $299,410

Grand Total All Awards = $2,299,008

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Rapid Point-of-Care RNA Diagnostic for Dengue Infection

Award Number: R44AI140813

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2019

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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