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Development of AAV vectors for long-term expression of eCD4-Ig

Award Number: R44AI134269
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2017
PERIOD OF PERFORMANCE END DATE: 07/31/2021

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Development of AAV vectors for long-term expression of eCD4-Ig - ABSTRACT / SUMMARY / PROJECT DESCRIPTION A single intramuscular injection of an adeno-associated virus (AAV) vector that expresses eCD4-Ig has the potential to treat or prevent HIV-1 infection for a lifetime. eCD4-Ig is a synthetic antibody or “immunoadhesin” constructed by fusing parts of the viral receptor (CD4) and coreceptor (CCR5) to the constant region of an antibody. Because eCD4-Ig binds the HIV-1 envelope glycoprotein (Env) through the same contacts used by Env to recognize its receptor and coreceptor, eCD4-Ig neutralizes 100% of HIV-1 isolates and presents fundamental barriers to viral escape. We have previously shown that rhesus macaques inoculated with AAV expressing eCD4-Ig exhibited sterilizing protection against high-dose intravenous challenges with simian- human immunodeficiency virus (SHIV). Now, we propose several practical innovations designed to maximize the concentrations of eCD4-Ig in plasma that are sustained over the long term by AAV-transduced muscle.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	EMMUNE, INC.	14155 US HIGHWAY 1 JUNO BEACH	JUNO BEACH	FL	33408	PALM BEACH	USA	Allergy and Infectious Diseases Research	000	4	4/15/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $999,443 )
2020	2020	EMMUNE, INC.	14155 US HIGHWAY 1 JUNO BEACH	JUNO BEACH	FL	33408	PALM BEACH	USA	Allergy and Infectious Diseases Research	000	4	7/20/2020	NON-COMPETING CONTINUATION	$999,443
														Subtotal = $999,443

Issue Date FY: 2019 ( Subtotal = $999,675 )
2019	2019	EMMUNE, INC.	130 SCRIPPS WAY BLDG B ROOM 112	JUPITER	FL	33458	PALM BEACH	USA	Allergy and Infectious Diseases Research	000	3	7/17/2019	NON-COMPETING CONTINUATION	$999,675
														Subtotal = $999,675

Issue Date FY: 2018 ( Subtotal = $999,959 )
2018	2018	EMMUNE, INC.	130 SCRIPPS WAY BLDG B ROOM 112	JUPITER	FL	33458	PALM BEACH	USA	Allergy and Infectious Diseases Research	001	2	8/27/2018	EXTENSION WITH OR WITHOUT FUNDS	$999,959
2018	2017	EMMUNE, INC.	130 SCRIPPS WAY BLDG B ROOM 112	JUPITER	FL	33458	PALM BEACH	USA	Allergy and Infectious Diseases Research	000	1	7/13/2018	NEW	$0
														Subtotal = $999,959

Issue Date FY: 2017 ( Subtotal = $299,239 )
2017	2017	EMMUNE, INC.	130 SCRIPPS WAY BLDG B ROOM 112	JUPITER	FL	33458	PALM BEACH	USA	Allergy and Infectious Diseases Research	000	1	7/25/2017	NEW	$299,239
														Subtotal = $299,239

Grand Total All Awards = $3,298,316

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Development of AAV vectors for long-term expression of eCD4-Ig

Award Number: R44AI134269

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2017

PERIOD OF PERFORMANCE END DATE: 07/31/2021

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