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A Topical Non-steroidal Anti-inflammatory for Atopic Dermatitis

Award Number: R44AI132065
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/14/2017
PERIOD OF PERFORMANCE END DATE: 01/31/2021

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A Topical Non-steroidal Anti-inflammatory for Atopic Dermatitis - SUMMARY Atopic dermatitis is a chronic dermatological condition afflicting mostly infants and young children. Current treatments are associated with a wide range of side effects therefore development of novel therapeutic agents that are efficacious and have an improved safety profile is needed. Although disease etiology has yet to be fully understood, skin inflammation is known to be critically involved in the disease pathology. Signum has identified two novel potent topical anti-inflammatory agents (lead compound - SIG1451, backup compound – SIG1456) called isoprenylcysteines (IPCs) with no detectable adverse affects. The proposed Phase IIB research plan will enable the filing of an investigational new drug (IND) application for the first in human trials in AD. In addition this grant proposal will buttress Post-IND clinical efforts by completing additional juvenile safety and continue drug substance and drug product development for Phase II clinical trials.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	SIGNUM BIOSCIENCES INC	11 DEERPARK DR	MONMOUTH JUNCTION	NJ	08852	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	6	11/17/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $778,244 )
2019	2019	SIGNUM BIOSCIENCES, INC.	11 DEERPARK DR STE 202	MONMOUTH JUNCTION	NJ	08852	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	6	1/31/2019	NON-COMPETING CONTINUATION	$778,244
														Subtotal = $778,244

Issue Date FY: 2018 ( Subtotal = $1,136,065 )
2018	2018	SIGNUM BIOSCIENCES, INC.	11 DEERPARK DR STE 202	MONMOUTH JUNCTION	NJ	08852	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	5	1/10/2018	NON-COMPETING CONTINUATION	$1,136,065
														Subtotal = $1,136,065

Issue Date FY: 2017 ( Subtotal = $1,050,155 )
2017	2017	SIGNUM BIOSCIENCES, INC.	11 DEERPARK DR STE 202	MONMOUTH JUNCTION	NJ	08852	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	4	2/13/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,050,155
														Subtotal = $1,050,155

Grand Total All Awards = $2,964,464

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A Topical Non-steroidal Anti-inflammatory for Atopic Dermatitis

Award Number: R44AI132065

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/14/2017

PERIOD OF PERFORMANCE END DATE: 01/31/2021

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