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Development of an H2O2-inactivated chikungunya virus vaccine

Award Number: R44AI128990
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2017
PERIOD OF PERFORMANCE END DATE: 02/28/2022

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Development of an H2O2-inactivated chikungunya virus vaccine - Chikungunya virus (CHIKV) is an alphavirus that has gained significant attention due to its ability to cause large epidemics among susceptible populations and to be spread beyond endemic countries by international travelers. Among a population of approximately 750,000 on the French island of La Reunion, 266,000 people were infected and over 200 CHIKV-related fatalities occurred during the 2006 outbreak. Likewise, an estimated 1.4 million people were infected with CHIKV in India during outbreaks that occurred from 2006 to 2007 and recently there have been more than 1.7 million people infected with CHIKV in the Caribbean and the Americas. At present, there is no commercial vaccine available for CHIKV. The development of an inactivated CHIKV vaccine suitable for immunizing the general population as well as vulnerable groups including infants and the elderly represents an important unmet clinical need. We have developed a versatile vaccine platform based on inactivating viruses with hydrogen peroxide (H2O2) and here, we present preclinical efficacy data demonstrating that our optimized prototype H2O2-CHIKV vaccine can provide complete protection against infection and CHIKV-associated pathology in a robust mouse model. Based on this innovative new approach to vaccine development and promising preclinical data with CHIKV, we propose a detailed research plan to perform all necessary IND-enabling studies and to manufacture clinical-grade H2O2-inactivated CHIKV vaccine suitable for Phase I trials.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2019	NAJIT TECHNOLOGIES, INC.	15232 NW GREENBRIER PKWY	BEAVERTON	OR	97006	WASHINGTON	USA	Allergy and Infectious Diseases Research	000	3	11/22/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	NAJIT TECHNOLOGIES, INC.	15232 NW GREENBRIER PKWY	BEAVERTON	OR	97006	WASHINGTON	USA	Allergy and Infectious Diseases Research	000	3	2/2/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	NAJIT TECHNOLOGIES, INC.	15232 NW GREENBRIER PKWY	BEAVERTON	OR	97006	WASHINGTON	USA	Allergy and Infectious Diseases Research	000	3	2/27/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $989,109 )
2019	2019	NAJIT TECHNOLOGIES, INC.	505 NW 185TH AVE	BEAVERTON	OR	97006	WASHINGTON	USA	Allergy and Infectious Diseases Research	000	3	2/7/2019	NON-COMPETING CONTINUATION	$989,109
2019	2019	NAJIT TECHNOLOGIES, INC.	15232 NW GREENBRIER PKWY	BEAVERTON	OR	97006	WASHINGTON	USA	Allergy and Infectious Diseases Research	001	3	9/12/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $989,109

Issue Date FY: 2018 ( Subtotal = $994,841 )
2018	2018	NAJIT TECHNOLOGIES, INC.	505 NW 185TH AVE	BEAVERTON	OR	97006	WASHINGTON	USA	Allergy and Infectious Diseases Research	000	2	2/16/2018	NON-COMPETING CONTINUATION	$994,841
														Subtotal = $994,841

Issue Date FY: 2017 ( Subtotal = $999,652 )
2017	2017	NAJIT TECHNOLOGIES, INC.	505 NW 185TH AVE	BEAVERTON	OR	97006	WASHINGTON	USA	Allergy and Infectious Diseases Research	000	1	2/28/2017	NEW	$999,652
														Subtotal = $999,652

Grand Total All Awards = $2,983,602

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Development of an H2O2-inactivated chikungunya virus vaccine

Award Number: R44AI128990

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2017

PERIOD OF PERFORMANCE END DATE: 02/28/2022

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