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DIAGNOSTIC INFLUENZA RT-PCR ARRAY

Award Number: R44AI072784
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2007
PERIOD OF PERFORMANCE END DATE: 06/30/2012

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DIAGNOSTIC INFLUENZA RT-PCR ARRAY - DESCRIPTION (provided by applicant): Influenza viruses are highly contagious negative-sense RNA viruses cause approximately 114,000 hospitalizations and 20,000 deaths annually. Several drugs are approved by the US Food and Drug Administration (FDA) for treating influenza infections, but successful treatment depends on knowing the specific antigenic subtype and administering these drugs within the first 48 h of illness. Recent outbreaks of avian influenza H5N1 in East Asia have fueled concern over another pandemic and emphasize the need for comprehensive strain sub-typing in surveillance and diagnostic applications. The objective of this Phase 2 Project is therefore to develop and field test a sample-to-answer RT-PCR array kit for influenza detection and antigenic sub-typing in diagnostic and surveillance settings, with an emphasis on simple, low-cost microarray technology that can be deployed and used in peripheral hospital labs. The performance goal is a sample-to answer result in 2 hours or less at an input target concentration of 102 viral particles per mL nasopharyngeal swab. Early adopters at Wadsworth Center, Columbia University, Little Company of Mary Hospital and the CDC will assist in the pre-clinical verification of the technology on amended and blind clinical samples. PUBLIC HEALTH RELEVANCE: The influenza RT-PCR array will be the first-of-its-kind combination of PCR and microarray technology in a simple, inexpensive test kit for disease surveillance and diagnosis. The underlying platform developed herein will likewise find broad application in many areas of infectious disease diagnostics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = $985,553 )
2011	2011	AKONNI BIOSYSTEMS INC	9702 WOODFIELD COURT	NEW MARKET	MD	21774	FREDERICK	USA	Allergy and Infectious Diseases Research	000	4	6/24/2011	NON-COMPETING CONTINUATION	$985,553
														Subtotal = $985,553

Issue Date FY: 2010 ( Subtotal = $980,513 )
2010	2010	AKONNI BIOSYSTEMS INC	9702 WOODFIELD COURT	NEW MARKET	MD	21774	FREDERICK	USA	Allergy and Infectious Diseases Research	000	3	6/16/2010	NON-COMPETING CONTINUATION	$980,513
														Subtotal = $980,513

Issue Date FY: 2009 ( Subtotal = $999,468 )
2009	2009	AKONNI BIOSYSTEMS INC	9702 WOODFIELD COURT	NEW MARKET	MD	21774	FREDERICK	USA	Allergy and Infectious Diseases Research	000	2	7/1/2009	COMPETING CONTINUATION	$999,468
														Subtotal = $999,468

Grand Total All Awards = $2,965,534

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DIAGNOSTIC INFLUENZA RT-PCR ARRAY

Award Number: R44AI072784

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2007

PERIOD OF PERFORMANCE END DATE: 06/30/2012

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