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FIND-seq: A Novel Cell Sorting Technology to Enable Investigation of Rare Cells in Primary Human Tissues

Award Number: R44AG091101
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/12/2025
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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FIND-seq: A Novel Cell Sorting Technology to Enable Investigation of Rare Cells in Primary Human Tissues - ABSTRACT Rare cells, such as pathogenic astrocytes, play an important role in tissue physiology and pathology, including neurodegenerative and CNS disorders. However, the investigation of these cells is often hindered by the lack of known surface markers to isolate them, which is necessary for in-depth profiling. FIND-seq, a novel cell sorting technology developed by Dr. Adam Abate, a founder of Fluid Discovery, which enables rare cells or nuclei to be isolated based on DNA or RNA markers with single molecule sensitivity, even in cases where no known surface markers are available. Fluid Discovery, is focused on commercializing FIND-seq for neurodegenerative disease research and broader single-cell genomics markets. This Fast-Track SBIR will support the translation of the technology from the lab to the company, its development into a first-generation commercial product, and its validation on an important neurodegenerative disease use-case. The successful completion of these aims is crucial for the commercialization of FIND-seq and for Fluid Discovery's ability to meet the growing demand for more effective and efficient rare cell sorting and sequencing technologies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	VIVID BIOINNOVATIONS, PBC	953 INDIANA ST	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	1	2/16/2026	NEW	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $306,871 )
2025	2025	FLUID DISCOVERY, INC.	953 INDIANA ST	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	1	9/12/2025	NEW	$306,871
														Subtotal = $306,871

Grand Total All Awards = $306,871

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FIND-seq: A Novel Cell Sorting Technology to Enable Investigation of Rare Cells in Primary Human Tissues

Award Number: R44AG091101

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/12/2025

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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