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PET Imaging of Damaging Neuroinflammation in Alzheimer's Disease Technical and Business Assistance (TABA)

Award Number: R44AG079734
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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PET Imaging of Damaging Neuroinflammation in Alzheimer's Disease Technical and Business Assistance (TABA) - Alzheimer’s disease (AD) is a devastating and progressive disease without a cure. Neuroinflammation is now recognized as a key early event in the development of AD. A non-invasive imaging method to detect and assess early damaging neuroinflammation would be able to detect disease before irreversible damage occurs. We at Einsenca are developing a PET imaging method to detect and monitor oxidative stress and consequent damaging neuroinflammation in AD. Intellectual property protections will be critical to future commercialization and ultimate clinical translation of these PET imaging methods. We request administrative supplement support for technical assistance with these intellectual property protections. Currently Einsenca possesses limited rights for development and validation of these PET imaging technologies that originated at academic partner Massachusetts General Hospital (MGH). TABA support will be used to fund ahighly experienced attorney from a full-service national law firm (Potomac Law Group) to evaluate the strength, validity, and enforceable nature of the patents intended to be exclusively licensed by Einsenca along with anticipated freedom to operate and commercialize the technology. Potomac Law Group will also assist Einsenca in the financial valuation of the technology and draft, negotiate and conclude the definitive exclusive license agreement between Einsenca and MGH. Finally, Potomac Law Group will draft templates and assist in negotiation of sponsored research, materials transfer, and confidentiality agreements important for development work with both commercial and academic partners.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	EINSENCA INC.	8 THE GRN STE 12964	DOVER	DE	19901	KENT	USA	Aging Research	001	2	9/22/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2024	EINSENCA INC.	8 THE GRN STE 12964	DOVER	DE	19901	KENT	USA	Aging Research	000	3	9/22/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	EINSENCA INC.	8 THE GRN STE 12964	DOVER	DE	19901	KENT	USA	Aging Research	000	3	8/20/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,386,772 )
2024	2024	EINSENCA INC.	8 THE GRN STE 12964	DOVER	DE	19901	KENT	USA	Aging Research	004	3	8/21/2024	NON-COMPETING CONTINUATION	$1,336,772
2024	2024	EINSENCA INC.	8 THE GRN STE 12964	DOVER	DE	19901	KENT	USA	Aging Research	001	2	12/14/2023	SUPPLEMENT FOR EXPANSION	$50,000
2024	2023	EINSENCA INC.	8 THE GRN STE 12964	DOVER	DE	19901	KENT	USA	Aging Research	000	2	10/13/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
2024	2023	EINSENCA INC.	8 THE GRN STE 12964	DOVER	DE	19901	KENT	USA	Aging Research	003	2	3/19/2024	EXTENSION WITH OR WITHOUT FUNDS	$2,281
2024	2022	EINSENCA INC.	8 THE GRN STE 12964	DOVER	DE	19901	KENT	USA	Aging Research	002	1	3/19/2024	NEW	-$2,281
														Subtotal = $1,386,772

Issue Date FY: 2023 ( Subtotal = $1,154,734 )
2023	2023	EINSENCA INC.	8 THE GRN STE 12964	DOVER	DE	19901	KENT	USA	Aging Research	001	2	9/12/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
2023	2023	EINSENCA INC.	8 THE GRN STE 12964	DOVER	DE	19901	KENT	USA	Aging Research	000	2	8/23/2023	EXTENSION WITH OR WITHOUT FUNDS	$1,154,734
														Subtotal = $1,154,734

Issue Date FY: 2022 ( Subtotal = $497,602 )
2022	2022	EINSENCA INC.	8 THE GRN STE 12964	DOVER	DE	19901	KENT	USA	Aging Research	000	1	8/29/2022	NEW	$497,602
														Subtotal = $497,602

Grand Total All Awards = $3,039,108

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PET Imaging of Damaging Neuroinflammation in Alzheimer's Disease Technical and Business Assistance (TABA)

Award Number: R44AG079734

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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