Thursday, November 6, 2025 11/6/2025

Remote STATE training for Insomnia in Older Adults

Award Number: R44AG076304
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Remote STATE training for Insomnia in Older Adults - PROJECT SUMMARY The goal of the current Phase II project is definitively evaluate the efficacy of a computerized cognitive training program (rSTATE) designed to improve sleep regulation and brain health and extend functional independence in older adults with insomnia. Nearly half of all adults over age sixty suffer disruptions in sleep that increase as a function of age. Nearly one third meet criteria for chronic insomnia, resulting in poor quality of life and increased risk of depression. Notably, cognitive decline in older adults with insomnia exceeds that observed in normal healthy aging. In addition to the obvious health and quality-of-life ramifications of late life insomnia, there are high economic costs. Thus, implementing scalable interventions to prevent functional dependence and cognitive impairment is of critical importance to overall public health. Here, we propose to evaluate a novel intervention that improve sleep, cognitive deficits and bolster functional abilities in patients with insomnia. Our preliminary data is among the first evidence to demonstrate that a neuroplasticity-based intervention has ‘real-world’ benefits and the potential to be a highly-scalable form of computerized cognitive training for providing protection against insomnia. At the completion of this project we will have outcomes data sufficient to support a compelling submission to the FDA for clearance as a medical device indicated for the treatment of insomnia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	POSIT SCIENCE CORP	160 PINE ST STE 200	SAN FRANCISCO	CA	94111	SAN FRANCISCO	USA	Aging Research	000	2	7/29/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $467,378 )
2023	2023	POSIT SCIENCE CORP	160 PINE ST	SAN FRANCISCO	CA	94111	SAN FRANCISCO	USA	Aging Research	001	2	9/8/2023	NON-COMPETING CONTINUATION	$467,378
2023	2022	POSIT SCIENCE CORP	160 PINE ST	SAN FRANCISCO	CA	94111	SAN FRANCISCO	USA	Aging Research	000	1	6/2/2023	NEW	$0
														Subtotal = $467,378

Issue Date FY: 2022 ( Subtotal = $534,429 )
2022	2022	POSIT SCIENCE CORPORATION	160 PINE ST STE 200	SAN FRANCISCO	CA	94111	SAN FRANCISCO	USA	Aging Research	000	1	8/31/2022	NEW	$534,429
														Subtotal = $534,429

Grand Total All Awards = $1,001,807

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Remote STATE training for Insomnia in Older Adults

Award Number: R44AG076304

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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