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Innovating Tablet-Based Cognitive Assessment for CNS Disorders of Aging

Award Number: R44AG053121
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2016
PERIOD OF PERFORMANCE END DATE: 10/31/2018

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Innovating Tablet-Based Cognitive Assessment for CNS Disorders of Aging - ¿ DESCRIPTION (provided by applicant): Aging populations have become a key target for therapeutics developers, particularly for indications impacting cognitive function. Conditions such as Alzheimer's disease and vascular dementia affect the quality of life of aging Americans, largely due to their impact on cognitive function, with insufficient therapeutic options. Recent reports indicate that early identification of at-risk individuals may help to slow progression and onset of cognitive decline. Thus, new cognitive tests, capable of screening patients for mild or moderate cognitive decline associated with the earliest stages of neurodegenerative disease, are urgently needed. Tests such as the ADAS-Cog (Alzheimer's Disease Assessment Scale - Cognitive subscale) lack sensitivity to milder forms of cognitive impairment, and are cumbersome and time-consuming to administer and score. Effective screening tests for cognitive impairment must be brief, simple to administer, and automatically scored. These tests must be tailored toward aging populations and demonstrate sensitivity to mild cognitive decline. In order to allow meaningful interpretation of individual's performance, well-powered, demographically-targeted normative studies are essential. "Pen and paper" testing remains largely the standard for the assessment of cognitive decline. Some recently developed computerized tests have demonstrated improvement in ease of use, data reliability and cost-effectiveness in most demographic groups. In the aging population, however, performance on computerized tests is often poorly correlated with performance on pen-and-paper tests, calling into question the validity of data collected with computerized tests in this population. The Brief Assessment of Cognition (BAC) test battery developed by NeuroCog Trials has been employed in a range of studies associated with cognitive impairment, and has recently been adapted as a computerized test, the BAC App, administered via iPad(r). In our company-funded "Phase I Report," we provide details regarding the development of the BAC App, as well as data from our validation study showing a strong correlation between performance on the pen-and-paper BAC and performance on the BAC App in aging adults. These data are extremely encouraging, and we propose to expand the number of tests included in the BAC App. This would allow for greater sensitivity to deficits in episodic memory and spatial working memory, which are among the earliest signs of cognitive decline, particularly in Alzheimer's. Our Phase II program will focus on integrating these new tests into the BAC App, conducting a well-powered normative data study in aging adults in collaboration with Dr. Kathleen Welsh-Bohmer (Duke University), and determining the ability of the BAC App to discern healthy subjects from those experiencing cognitive decline. Successful completion of the Phase II program will enable NeuroCog Trials to offer the BAC App in cognitive decline studies specific to aging populations, a need reflected in both the literature and recent feedback from NeuroCog's customers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	NCT HOLDINGS, INC.	3211 SHANNON RD STE 300	DURHAM	NC	27707	DURHAM	USA	Aging Research	000	2	5/13/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $660,103 )
2017	2017	NCT HOLDINGS, INC.	3211 SHANNON RD STE 300	DURHAM	NC	27707	DURHAM	USA	Aging Research	000	2	5/5/2017	NON-COMPETING CONTINUATION	$660,103
														Subtotal = $660,103

Issue Date FY: 2016 ( Subtotal = $711,254 )
2016	2016	NEUROCOG TRIALS INC	3211 SHANNON ROAD	DURHAM	NC	27707	DURHAM	USA	Aging Research	000	1	5/5/2016	NEW	$711,254
														Subtotal = $711,254

Grand Total All Awards = $1,371,357

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Innovating Tablet-Based Cognitive Assessment for CNS Disorders of Aging

Award Number: R44AG053121

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2016

PERIOD OF PERFORMANCE END DATE: 10/31/2018

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