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Multi-site longitudinal Integrated Neurocognitive and Sleep-Behavior Profiler for the Endophenotypic Classification of Dementia Subtypes (INSPECDS)

Award Number: R44AG050326
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Multi-site longitudinal Integrated Neurocognitive and Sleep-Behavior Profiler for the Endophenotypic Classification of Dementia Subtypes (INSPECDS) - It is estimated that Alzheimer’s and other neurodegenerative diseases causing dementia will surpass cancer as the second leading cause of death by the year 2040. Alzheimer’s disease (AD) is the leading cause of dementia, followed by synucleinopathies, including dementia with Lewy bodies (DLB), Parkinson’s disease with dementia (PDD), and Fronto-temporal dementia. There is an urgent, unmet need for effective tools to aid in the classification of dementia subtypes, in the earliest detectable stages of the pathophysiological process. To address this, Advanced Brain Monitoring (ABM) is leveraging day/night assessment technologies to create the Integrated Neurocognitive and Sleep-Behavior Profiler for the Endophenotypic Classification of Dementia Subtypes (INSPECDS) to profile Alzheimer’s and other dementias. The components of the platform are the Alertness and Memory Profiler (AMP), the Sleep Profiler (SP), and integrated machine-learning, classification algorithms, hosted on a secure cloud-based, infrastructure for automated data processing, analysis, & reporting. AMP is unique among neurocognitive testing platforms in that it is the only one that integrates advanced electrophysiological measures (e.g., 24-channel wireless EEG/ECG) during the performance of computerized neurocognitive tasks and has proven effective in characterizing cognitive decline in Alzheimer’s disease. This capability permits researchers to explore real-time relations between fluctuations in alertness, discrete cognitive functions, and specific neural processes believed to subserve observed performance deficits in Alzheimer’s disease and other dementias. The SP is FDA-cleared, easily applied, wireless-EEG device that was developed and validated to measure sleep architecture for in-home sleep studies with submental EMG and wireless accelerometers to monitor head and limb movements to quantify the characteristics of REM-sleep behavior disorder, considered to be a prodromal expression of synucleinopathy. The application of machine-learning, classification algorithms streamlines the processing and analyses of these data to derive statistical probabilities of Alzheimer’s disease and other dementia subtypes. The overarching goal of the current submission is to finalize implementation of a secure, cloud-based infrastructure to compile the data obtained from the AMP and SP, train classification algorithms to discriminate among Alzheimer’s disease and other dementia subtypes, validate diagnostic accuracy, and integrate optimized classifiers within the cloud-based architecture. The INSPECDS system is the first clinical research tool of its kind with application in both university-based research settings and pharmaceutical clinical trials to aid in the endophenotypic stratification of Alzheimer’s disease and other dementias.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $955,309 )
2024	2024	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	000	5	7/10/2024	NON-COMPETING CONTINUATION	$955,309
														Subtotal = $955,309

Issue Date FY: 2023 ( Subtotal = $953,026 )
2023	2023	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE STE 100	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	002	4	5/18/2023	NON-COMPETING CONTINUATION	$978,121
2023	2022	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE STE 100	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	001	3	11/21/2022	COMPETING CONTINUATION	$0
2023	2017	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	000	2	10/1/2022	NON-COMPETING CONTINUATION	-$25,095
														Subtotal = $953,026

Issue Date FY: 2022 ( Subtotal = $932,880 )
2022	2022	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE STE 100	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	001	3	9/20/2022	COMPETING CONTINUATION	$999,922
2022	2017	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE STE 100	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	000	2	9/19/2022	NON-COMPETING CONTINUATION	-$67,042
														Subtotal = $932,880

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE STE 100	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	000	2	5/1/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE STE 100	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	000	2	5/17/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $727,746 )
2017	2017	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE STE 100	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	000	2	5/16/2017	NON-COMPETING CONTINUATION	$727,746
														Subtotal = $727,746

Issue Date FY: 2016 ( Subtotal = $710,663 )
2016	2016	ADVANCED BRAIN MONITORING, INC	2237 Faraday Ave Ste 100	Carlsbad	CA	92008	SAN DIEGO	USA	Aging Research	000	1	9/27/2016	NEW	$710,663
														Subtotal = $710,663

Grand Total All Awards = $4,279,624

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Multi-site longitudinal Integrated Neurocognitive and Sleep-Behavior Profiler for the Endophenotypic Classification of Dementia Subtypes (INSPECDS)

Award Number: R44AG050326

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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