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NUTRITIONAL INTERVENTION FOR OLDER ADULT MUSCLE LOSS

Award Number: R44AG020897
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2003
PERIOD OF PERFORMANCE END DATE: 08/31/2006

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NUTRITIONAL INTERVENTION FOR OLDER ADULT MUSCLE LOSS - DESCRIPTION (provided by applicant): Age-related muscle loss is a major public health issue affecting over 30 million Americans, with no viable treatments available to stem about an 8% loss in muscle mass every decade. Preliminary studies with beta-hydroxy-beta-methylbutyrate, arginine, and lysine (HMB/ARG/LYS) indicate a reversal of age-related muscle loss is possible, at least with women. Limited data collection on elderly men suggest HMB/ARG/LYS may not have an effect. The proposed study will expand on these preliminary studies in women to determine whether a combination of HMB, arginine, and lysine is effective in increasing whole body protein synthesis, fat-free mass, strength and functionality in both older adult men and women. Thirty-two subjects (16 men and 16 women) over the age of 65 years will be recruited and will be assigned to an isonitrogenous control treatment (n=16) or to the experimental treatment group (n=l 6) containing HMB (calcium salt), arginine, and lysine daily (HMB/ARG/LYS) for six weeks. Whole body protein turnover, body composition, strength and functionality will be used as measures of effectiveness. It is hypothesized that this mixture will support maximal protein synthesis and minimize proteolysis resulting in an increase in net protein balance. If proven effective in Phase I, the overall objective of Phase II of this research will be to test the long-term (12 month) efficacy of this nutrient mixture to prevent and reverse the loss of muscle mass, strength, and functionality that occurs in older adults.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $363,674 )
2005	2005	METABOLIC TECHNOLOGIES, INC	2625 NORTH LOOP DR, STE 2150	AMES	IA	50010	STORY	USA	Aging Research	000	3	8/8/2005	NON-COMPETING CONTINUATION	$363,674
														Subtotal = $363,674

Issue Date FY: 2004 ( Subtotal = $379,424 )
2004	2004	METABOLIC TECHNOLOGIES, INC	2625 NORTH LOOP DR, STE 2150	AMES	IA	50010	STORY	USA	Aging Research	000	2	7/6/2004	EXTENSION WITH OR WITHOUT FUNDS	$379,424
														Subtotal = $379,424

Issue Date FY: 2003 ( Subtotal = $100,001 )
2003	2003	METABOLIC TECHNOLOGIES, INC	2625 NORTH LOOP DR, STE 2150	AMES	IA	50010	STORY	USA	Aging Research	000	1	7/30/2003	NEW	$100,001
														Subtotal = $100,001

Grand Total All Awards = $843,099

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NUTRITIONAL INTERVENTION FOR OLDER ADULT MUSCLE LOSS

Award Number: R44AG020897

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2003

PERIOD OF PERFORMANCE END DATE: 08/31/2006

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