Monday, January 19, 2026 1/19/2026

Characterization of a novel non-hallucinogenic psilocybin derivative for alcohol use disorder

Award Number: R44AA031925
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2025
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Characterization of a novel non-hallucinogenic psilocybin derivative for alcohol use disorder - Abstract The use of psychedelic molecules in the treatment of alcohol/substance abuse and mental health disorders is one of the most controversial topics in modern society. This skepticism is due to its historic recreational use for hallucinogenic effects and potential for abuse. However, recent investigations specifically around psilocybin and derivatives reveal increasing evidence for their therapeutic use in mental health, neurocognitive, and substance abuse disorders. Safe and effective treatments for each of the aforementioned ailments require greater attention as we progress as a society. We have performed detailed structure-activity relationship analyses of various tryptamine analogs to probe their biological properties and develop effective treatments with reduced hallucinogenic properties. This proposal provides a detailed plan to further develop a more selective serotonergic-targeting, non- hallucinogenic psilocybin derivative for alcohol use disorders with promising preliminary efficacy in alcohol preferring mice that surpass the activity of psilocin over a 60-day dosing period.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	PSILERA, INC.	3802 SPECTRUM BLVD STE 136B	TAMPA	FL	33612	HILLSBOROUGH	USA	Alcohol Research Programs	000	1	12/22/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $320,263 )
2025	2025	PSILERA, INC.	3802 SPECTRUM BLVD STE 136B	TAMPA	FL	33612	HILLSBOROUGH	USA	Alcohol Research Programs	000	1	9/10/2025	NEW	$320,263
														Subtotal = $320,263

Grand Total All Awards = $320,263

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Characterization of a novel non-hallucinogenic psilocybin derivative for alcohol use disorder

Award Number: R44AA031925

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2025

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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