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Non-invasive Blood Alcohol Sensor for Emergency Room Applications

Award Number: R44AA020449
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/10/2011
PERIOD OF PERFORMANCE END DATE: 08/31/2017

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Non-invasive Blood Alcohol Sensor for Emergency Room Applications - DESCRIPTION (provided by applicant): Project Summary Accurate quantification of alcohol and drugs of abuse intoxication in emergency rooms (ERs) is an important screening step for a precise diagnosis and hence for prompt treatment. Some severe emergencies such as traumatic head injury, diabetes, and stroke can be misdiagnosed in the absence of screening for alcohol and drug intoxication; reliable measurement of alcohol and drug intake levels would improve diagnosis and subsequent treatment in these cases. Most methods now used in emergency rooms either require patient cooperation and interaction, such as a Breathalyzer, or are invasive and have prolonged processing times, such as blood and urine sample analysis, making them inappropriate for ER applications. In particular, patients suffering from drug and alcohol intoxication are often not able, or are unwilling, to interact with medical personnel, hence the need for easier sampling and reliable measurement. To address this need, Intelligent Optical Systems is collaborating with Dr. Robert Woolard of Texas Tech University Health Science Center (TTUHSC) Emergency Medicine Department, a recognized expert in alcohol and drugs of abuse in ER-related studies, in our development for a non-invasive saliva-based analyzer for ER applications. The analyzer measures emissions of fluorescent-labeled selective reagents to detect alcohol and drugs of abuse in saliva samples. Although saliva monitoring is an established area for alcohol and drugs of abuse, accurate quantitative measurements are still needed to quantify the intoxication levels in admitted ER patients without relying on visual judgments. In Phase I we demonstrated the feasibility of achieving reproducible, highly sensitive measurements of alcohol levels in buffer and modeled saliva, as well as in 30 human saliva samples obtained by Dr. Woolard and TTUHSC that were tested and compared to blood levels. In Phase II we will test an additional 100 human samples to expand the statistical data and determine sensor accuracy and precision levels, introduce a method for quantitative (high/mid/low) measurement of six drugs of abuse (opiates, cocaine, amphetamines, THC, benzodiazepines, barbiturates), and develop the portable readout system. The objective is a simple yet highly accurate optical detection platform suitable for bedside ER applications, with further potential for widespread clinical monitoring applications in many healthcare settings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = -$96,258 )
2018	2015	INTELLIGENT OPTICAL SYSTEMS, INC.	2520 W 237TH ST	TORRANCE	CA	90505	LOS ANGELES	USA	Alcohol Research Programs	001	4	3/1/2018	NON-COMPETING CONTINUATION	-$96,258
2018	2015	INTELLIGENT OPTICAL SYSTEMS, INC.	2520 W 237TH ST	TORRANCE	CA	90505	LOS ANGELES	USA	Alcohol Research Programs	000	4	12/19/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = -$96,258

Issue Date FY: 2015 ( Subtotal = $739,285 )
2015	2015	INTELLIGENT OPTICAL SYSTEMS, INC	2520 WEST 237TH STREET	TORRANCE	CA	90505	LOS ANGELES	USA	Alcohol Research Programs	000	4	8/11/2015	NON-COMPETING CONTINUATION	$717,106
2015	2015	INTELLIGENT OPTICAL SYSTEMS, INC	2520 WEST 237TH STREET	TORRANCE	CA	90505	LOS ANGELES	USA	Alcohol Research Programs	001	4	8/12/2015	NON-COMPETING CONTINUATION	$22,179
														Subtotal = $739,285

Issue Date FY: 2014 ( Subtotal = $739,288 )
2014	2014	INTELLIGENT OPTICAL SYSTEMS, INC	2520 WEST 237TH STREET	TORRANCE	CA	90505	LOS ANGELES	USA	Alcohol Research Programs	001	3	9/5/2014	NON-COMPETING CONTINUATION	$22,179
2014	2014	INTELLIGENT OPTICAL SYSTEMS, INC	2520 WEST 237TH STREET	TORRANCE	CA	90505	LOS ANGELES	USA	Alcohol Research Programs	000	3	8/1/2014	NON-COMPETING CONTINUATION	$717,109
														Subtotal = $739,288

Issue Date FY: 2013 ( Subtotal = $739,287 )
2013	2013	INTELLIGENT OPTICAL SYSTEMS, INC	2520 WEST 237TH STREET	TORRANCE	CA	90505	LOS ANGELES	USA	Alcohol Research Programs	000	2	9/16/2013	COMPETING CONTINUATION	$739,287
														Subtotal = $739,287

Grand Total All Awards = $2,121,602

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Non-invasive Blood Alcohol Sensor for Emergency Room Applications

Award Number: R44AA020449

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/10/2011

PERIOD OF PERFORMANCE END DATE: 08/31/2017

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