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Immobilized Cofactor Regeneration Systems to Accelerate Enzymatic API Manufacturing

Award Number: R43TR006332
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2026
PERIOD OF PERFORMANCE END DATE: 08/14/2027

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Immobilized Cofactor Regeneration Systems to Accelerate Enzymatic API Manufacturing - Title: Immobilized Cofactor Regeneration Systems to Accelerate Enzymatic API Manufacturing Cascade Biocatalysts Inc. Project Summary/Abstract Enzymes – nature’s catalysts – are recognized as a powerful approach for pharmaceutical manufacturing. Enzymatic processes can replace traditional chemical routes with methods that are more selective, operate under mild conditions, and open access to novel drug chemistries previously inaccessible to manufacturers. These advantages are especially important for strengthening U.S. capacity to produce medicines, reducing reliance on global supply chains, and supporting less resource intensive domestic manufacturing. Despite these benefits, widespread adoption of biocatalysis is limited by the poor stability of enzymes under process conditions and the complexity of recycling required cofactors. Since nearly half of all enzymes require a cofactor, this challenge restricts the use of a large portion of nature’s catalytic toolkit. To address this, we will expand an enzyme immobilization platform by incorporating cofactor regeneration systems directly into immobilized resins, enabling broader application of redox enzymes and transferases in pharmaceutical synthesis. Our research strategy includes the design and synthesis of immobilized cofactor-regeneration resins, followed by rigorous evaluation of stability, activity, and reusability in representative pharmaceutical reactions. Success will establish a broadly applicable platform that reduces barriers to implementing biocatalysis earlier in drug process development. The long-term objective is to accelerate the adoption of enzyme-based manufacturing routes, increasing efficiency and resilience of domestic pharmaceutical production while opening new opportunities for innovative medicines.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $306,871 )
2026	2026	CASCADE BIOCATALYSTS INC.	3960 NIAGARA ST STE B	DENVER	CO	80207	DENVER	USA	National Center for Advancing Translational Sciences	000	1	8/5/2026	NEW	$306,871
														Subtotal = $306,871

Grand Total All Awards = $306,871

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Immobilized Cofactor Regeneration Systems to Accelerate Enzymatic API Manufacturing

Award Number: R43TR006332

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2026

PERIOD OF PERFORMANCE END DATE: 08/14/2027

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