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High Throughput Magnetic Assisted Transfection Platform for Autologous Hematopoietic Stem Cell Therapies

Award Number: R43TR002701
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Gene modified autologous hematopoietic stem cell transplantation is a transformative approach for treating variety of blood cancers and immunodeficiency disorders. However, the current methods for therapy manufacture need substantial quantities of costly GMP grade viral vectors to deliver the nucleic acids for deriving therapeutic cells. The high cost and limited supply of GMP grade vectors contributes to large expenses incurred by patients as well as long waiting lists which delay patient treatment. Additionally, vector availability to clinical researchers developing new therapies is also reduced which slows clinical translation. While other non-vector- based methods for nucleic acid delivery are available, they have disadvantages in working with delicate stem cells such as low cell viability and highly delivery efficiency which limits their clinical applicability. Ferrologix proposes to develop a modular product that can achieve a =10 fold reduction in the quantity of vector necessary to produce a therapeutic cell batch compared to the current co-culture methods. Utilizing arrays of ferromagnetic micropillars, magnetically tagged target cells and viral vector can be concentrated to discrete points for highly controlled exposure. By confining the volume of cells and vector, precision vector mediated nucleic acid delivery can be achieved. In this phase I submission we propose to develop a magnetic transduction platform that can significantly reduce per batch vector consumption, which can lead to more rapid clinical translation of new therapies and scaled patient treatment capabilities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2019	FERROLOGIX INC	23328 BARFIELD DR	VALENCIA	CA	91354	LOS ANGELES	USA	National Center for Advancing Translational Sciences	000	1	11/9/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	FERROLOGIX, INC.	23328 BARFIELD DR	VALENCIA	CA	91354	LOS ANGELES	USA	National Center for Advancing Translational Sciences	000	1	6/25/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $323,578 )
2019	2019	FERROLOGIX	1916 ROBINSON ST	REDONDO BEACH	CA	90278	LOS ANGELES	USA	National Center for Advancing Translational Sciences	000	1	8/27/2019	NEW	$323,578
														Subtotal = $323,578

Grand Total All Awards = $323,578

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High Throughput Magnetic Assisted Transfection Platform for Autologous Hematopoietic Stem Cell Therapies

Award Number: R43TR002701

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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