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VESTIBULAR-TOPOGRAPHICAL MEMORY MARKERS FOR THOSE AT RISK FOR ALZHEIMER'S DISEASE

Award Number: R43TR000645
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2012
PERIOD OF PERFORMANCE END DATE: 04/30/2013

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VESTIBULAR-TOPOGRAPHICAL MEMORY MARKERS FOR THOSE AT RISK FOR ALZHEIMER'S DISEASE - DESCRIPTION (provided by applicant): Despite years of research, the cause of Alzheimer's disease remains essentially unknown. Topographic memory impairments are arguably the earliest cognitive deficits observed in Alzheimer's disease, and the brain areas involved in topographic memory are the first to show degenerative changes. Previous research has shown a link between impairment of topographic memory in humans with bilateral vestibular loss. However, no one has heretofore attempted to correlate topographic memory loss with impairment of the vestibular system in individual members of a normal elderly population at risk for Alzheimer's disease. This Phase I project will develop biobehavioral markers for topographic memory impairments and their possible antecedents. These topographic and possible vestibular biobehavioral markers will be integrated into a web-based interface and decision-support system that will provide an early warning indicator for those at risk of topographic memory failure and possibly Alzheimer's disease. Ultimately, this system may be used not only to identify those at risks for Alzheimer's disease, but also those who may be amenable to vestibular remediation. The development of the biobehavioral markers has the potential to have a profound impact on public health and achieve significant commercial success. This Phase I study has two Specific Aims: Specific Aim 1. Create Software to Evaluate Topographic Memory and/or Vestibular Impairment Specific Aim 2. Evaluate the Correlation between Topographic Memory and Vestibular Function in a Human Clinical Trial PUBLIC HEALTH RELEVANCE: An estimated 5.4 million Americans have Alzheimer's disease in 2012. Payments for care associated with Alzheimer's disease are estimated to be $200 billion annually. Despite years of research, the cause of Alzheimer's disease remains largely unknown. The development of biobehavioral markers that could indicate early onset of Alzheimer's disease and perhaps provide targets for disease prevention or treatment would have a significant impact on public health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2012 ( Subtotal = $199,759 )
2012	2012	BIOMEDICAL DEVELOPMENT CORPORATION	PO BOX 6660	SAN ANTONIO	TX	78209	BEXAR	USA	National Center for Advancing Translational Sciences	000	1	9/20/2012	NEW	$199,759
														Subtotal = $199,759

Grand Total All Awards = $199,759

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VESTIBULAR-TOPOGRAPHICAL MEMORY MARKERS FOR THOSE AT RISK FOR ALZHEIMER'S DISEASE

Award Number: R43TR000645

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2012

PERIOD OF PERFORMANCE END DATE: 04/30/2013

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