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MICROBIAL PLATFORM FOR ACCESSING PLANT ALKALOIDS

Award Number: R43TR000616
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2013
PERIOD OF PERFORMANCE END DATE: 06/14/2014

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MICROBIAL PLATFORM FOR ACCESSING PLANT ALKALOIDS - DESCRIPTION: Plant-derived secondary metabolites have proven to be a rich source of pharmaceuticals. From 1981 to 2010, over 65% of the 1355 new chemical entities introduced worldwide were natural products or natural product derivatives. The benzylisoquinoline alkaloids (BIAs) represent a diverse class of secondary metabolites (2500 known structures) with a broad range of pharmacological activities. Efforts to develop new chemical entities sourced or derived from plant secondary metabolites have largely faltered, because (a) the complexity and stereochemistry of natural products is difficult to access via synthetic chemistry and (b) the yiel of natural products extracted directly from plants can be insufficient to capture the full range of natural products present in a particular species. The goal of our Phase I work is to do a proof-of-concept demonstration that we can (a) make a microbial chassis for the production of the BIA key intermediate (S)-reticuline based on the naturally occurring pathway found in some plants and (b) show that the chassis can be used to make a small set of BIAs derived from reticuline. Future effort will be based on this BIA chassis strain and will focus on the development of specialized strains targeting a particular molecule or natural product scaffold.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $150,000 )
2013	2013	GINKGO BIOWORKS INC	27 DRYDOCK AVENUE	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	1	6/11/2013	NEW	$135,000
2013	2013	GINKGO BIOWORKS INC	27 DRYDOCK AVENUE	BOSTON	MA	02210	SUFFOLK	USA	National Center for Advancing Translational Sciences	001	1	7/17/2013	NEW	$15,000
														Subtotal = $150,000

Grand Total All Awards = $150,000

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MICROBIAL PLATFORM FOR ACCESSING PLANT ALKALOIDS

Award Number: R43TR000616

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2013

PERIOD OF PERFORMANCE END DATE: 06/14/2014

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