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Tools and Methods for Producing High Quality Functional Protein Microarrays for Biomarker Discovery

Award Number: R43OD024970
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2018
PERIOD OF PERFORMANCE END DATE: 08/31/2021

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Tools and Methods for Producing High Quality Functional Protein Microarrays for Biomarker Discovery - Abstract: Functional protein microarrays find applications in high throughput disease biomarker discovery, understanding the incidence and role of post translational modifications (PTMs) in disease pathology, investigating activity and function of enzymes, protein–protein and protein– small molecule interactions, among others. Nucleic Acid Programmable Protein Array (NAPPA) technology is a robust method for producing cell-free in situ expressed functional protein microarrays in human lysate, freshly expressed and displayed at the time of assay, and has been widely applied in disease biomarker discovery research over the last decade. We aim to develop an advanced instrument for automating the production of NAPPA IPC (Isolated Protein Capture) high density protein microarrays on glass slides. Once the instrument is developed, we expect similar improvements in simplicity, speed and quality of NAPPA protein microarray assays as was seen when DNA microarrays were transferred from manual to automated workstations. In addition to clinical biomarker research, it is an ideal platform for profiling for disease biomarkers in animal models, a subset of which can then be monitored as prognostic biomarkers, indicators of end points in drug development pre-clinical trials.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2019	SPOC PROTEOMICS INC.	7201 E HENKEL WAY STE 285	SCOTTSDALE	AZ	85255	MARICOPA	USA	National Center for Advancing Translational Sciences	000	2	12/6/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = -$2 )
2023	2019	SPOC PROTEOMICS INC.	7201 E HENKEL WAY STE 285	SCOTTSDALE	AZ	85255	MARICOPA	USA	Research Infrastructure Programs	001	2	2/2/2023	SUPPLEMENT FOR EXPANSION	-$1
2023	2019	SPOC PROTEOMICS INC.	7201 E HENKEL WAY STE 285	SCOTTSDALE	AZ	85255	MARICOPA	USA	National Center for Advancing Translational Sciences	000	2	2/2/2023	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$2

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	INANOBIO, INC.	7201 E HENKEL WAY STE 285	SCOTTSDALE	AZ	85255	MARICOPA	USA	National Center for Advancing Translational Sciences	000	2	12/19/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $521,592 )
2019	2019	INANOBIO, INC.	1430 W AUTO DR STE 101	TEMPE	AZ	85284	MARICOPA	USA	National Center for Advancing Translational Sciences	000	2	8/22/2019	NON-COMPETING CONTINUATION	$349,552
2019	2019	INANOBIO, INC.	1430 W AUTO DR STE 101	TEMPE	AZ	85284	MARICOPA	USA	Research Infrastructure Programs	001	2	8/26/2019	SUPPLEMENT FOR EXPANSION	$172,040
														Subtotal = $521,592

Issue Date FY: 2018 ( Subtotal = $349,570 )
2018	2018	INANOBIO, INC.	1430 W AUTO DR STE 101	TEMPE	AZ	85284	MARICOPA	USA	National Center for Advancing Translational Sciences	000	1	8/21/2018	NEW	$349,570
														Subtotal = $349,570

Grand Total All Awards = $871,160

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Tools and Methods for Producing High Quality Functional Protein Microarrays for Biomarker Discovery

Award Number: R43OD024970

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2018

PERIOD OF PERFORMANCE END DATE: 08/31/2021

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