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Creating a bioluminescent mouse model for fast screening of drugs

Award Number: R43OD023258
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2017
PERIOD OF PERFORMANCE END DATE: 02/14/2019

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Creating a bioluminescent mouse model for fast screening of drugs - Abstract We propose an easy way to quickly generate reporter mice without genetic manipulation of animals for the application in the drug development. The generated reporter mice performs like transgenic mice, which have ubiquitously embedded reporters that are needed to monitor a particular cellular or molecular process over an extended time frame. Also the attachment of reporters to mice don’t interfere with naturally occurring processes. This proposal aims to examine a reporter system consisting of our reporter mice and a newly discovered imaging biomarker to address the challenges in creating a universal biomarker imaging for monitoring efficacy and safety of drugs. By using the new reporter system, we have successfully detected dynamic cellular responses to drugs in toxicological models. We expect to establish a general imaging protocol for quick assessing efficacy and toxicity of drugs through the study of this proposal.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	THERAMIX LLC	1045 CALIFORNIA ST STE A	MOUNTAIN VIEW	CA	94041	SANTA CLARA	USA	Research Infrastructure Programs	000	1	7/18/2019	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $217,130 )
2017	2017	THERAMIX LLC	1045 CALIFORNIA ST STE A	MOUNTAIN VIEW	CA	94041	SANTA CLARA	USA	Research Infrastructure Programs	000	1	8/11/2017	NEW	$217,130
														Subtotal = $217,130

Grand Total All Awards = $217,130

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Creating a bioluminescent mouse model for fast screening of drugs

Award Number: R43OD023258

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2017

PERIOD OF PERFORMANCE END DATE: 02/14/2019

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