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Wireless Control Vivarium System for Automated Microdosing

Award Number: R43OD020306
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/12/2015
PERIOD OF PERFORMANCE END DATE: 04/30/2018

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Wireless Control Vivarium System for Automated Microdosing - ¿ DESCRIPTION (provided by applicant): Drug administration is an essential tool in laboratory animal research that enables studies ranging from basic molecular/cellular mechanisms to drug discovery to preclinical development of new therapies. However, there is a significant technological gap in the development of advanced dosing strategies; current technologies do not meet the needs of animal care providers and researchers across academia and industry. The development of autonomous dosing in laboratory animals is necessary to improve drug administration capabilities and also enhance the use and management of laboratory animals. To address the critical needs of stress-free animal care and handling, the arrayable and wireless FluidSyncTM microinfusion system is proposed to enable automated, high throughput drug administration in an "intelligent vivarium." Rodents housed in integrated vivarium cage rack units will have FluidSyncTM miniature infusion pumps implanted subcutaneously. These pumps are individually controlled using wireless telemetry and a software interface that allows a single user to program, automate, and execute fully-customized dosing regimens across multiple animals in a study. This novel system will achieve the first automated dosing of multiple rodents housed across a large array of cages in a standard vivarium rack in a remotely controlled and on-demand manner. This unique capability will allow researchers to realize complex dosing schemes with fine temporal control. Since the pumps are refillable, chronic dosing is easily achieved with minimal handling of animals. The electronically controlled regimens developed using our system are compatible with emerging clinical technologies for the chronic drug management of conditions such as diabetes, pain, and neurological deficits. This technology will have significant impact at the early stages of the drug discovery and development pipeline by making available complex regimens of modern electronic clinical infusion systems. The ability to gain full control of the frequency, rate, and volume of drug administration will allow operational efficiency and rapid optimization of regimens for maximal therapeutic efficacy. This SBIR Phase 1 proposal addresses (1) significant challenges in controlling multiple miniaturized pumps per cage (up to 5) in an array of cages simultaneously (up to 9) and (2) integrating this system with a high-density vivaria caging system and (3) providing in vivo validation of the full wireless mult-pump system. These feasibility objectives will provide the foundation for a Phase 2 proposal aimed at expansion of the system beyond 9 cages and deployment to multiple vivaria making this innovation available for research, veterinary, and preclinical applications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	FLUID SYNCHRONY, LLC	892 N FAIR OAKS AVE	PASADENA	CA	91103	LOS ANGELES	USA	Research Infrastructure Programs	000	2	9/18/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	FLUID SYNCHRONY, LLC	892 N FAIR OAKS AVE	PASADENA	CA	91103	LOS ANGELES	USA	Research Infrastructure Programs	000	2	5/16/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $327,759 )
2016	2016	FLUID SYNCHRONY LLC	228 SOUTH OLIVE AVENUE	ALHAMBRA	CA	91801	LOS ANGELES	USA	Research Infrastructure Programs	000	2	4/15/2016	NON-COMPETING CONTINUATION	$327,759
														Subtotal = $327,759

Issue Date FY: 2015 ( Subtotal = $327,759 )
2015	2015	FLUID SYNCHRONY LLC	228 SOUTH OLIVE AVENUE	ALHAMBRA	CA	91801	LOS ANGELES	USA	Research Infrastructure Programs	000	1	5/11/2015	NEW	$327,759
														Subtotal = $327,759

Grand Total All Awards = $655,518

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Wireless Control Vivarium System for Automated Microdosing

Award Number: R43OD020306

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/12/2015

PERIOD OF PERFORMANCE END DATE: 04/30/2018

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