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Detecting Drug-Induced Hypoventilation and Verbally Prompting for Patient Self-Rescue

Award Number: R43NR015955
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/16/2016
PERIOD OF PERFORMANCE END DATE: 01/31/2018

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Detecting Drug-Induced Hypoventilation and Verbally Prompting for Patient Self-Rescue - PROJECT SUMMARY/ABSTRACT This Phase 1 SBIR proposal focuses on increasing ventilation safety for patients as they recover from surgery in the hospital while also reducing the work burden for clinicians. The underlying cause in 2 of every 3 unexpected hospital deaths is hypoventilation, a condition in which patients do not breathe enough. After surgery, many patients receive medication to control pain which can severely reduce their drive to breathe. The patient deaths that follow are clearly preventable if hypoventilation is detected early and the patient is awakened and prompted to breathe. In this project, we will build on a promising preliminary study to further develop an automated system that interacts directly with the patient to prompt them to breathe and is intuitive for clinicians to use. We plan to place a small wireless motion sensor and a low- cost pulse oximeter on the finger and a respiration monitor on the nose. When these sensors detect hypoventilation and very little hand motion with low oxygen saturation, the automated system will use a speaker by the bedside to wake the patient and directly verbally prompt them by name to breathe. If the patient does not respond, the system will immediately notify the nurse that help is needed. A display of breath prompting, breath rate and oxygen saturation history will help clinicians decide whether medication doses should be adjusted to prevent further hypoventilation. This proposal will allow advancement of the hardware, algorithm and user interface used in preliminary work as well as conduct a human clinical study to assess effectiveness and reduction in nurse workload. In Phase II, the device will be refined and tested in patients on the general floor. Axon's team has demonstrated commercial success with several devices and looks forward to bringing this device through FDA 510(k) to commercialization and preventing unexpected hospital deaths from hypoventilation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = -$3 )
2018	2016	AXON MEDICAL INC	3478 WEST 2100 SOUTH #300	SALT LAKE CITY	UT	84119	SALT LAKE	USA	Nursing Research	000	1	10/16/2017	NEW	$0
2018	2016	AXON MEDICAL INC	3478 WEST 2100 SOUTH #300	SALT LAKE CITY	UT	84119	SALT LAKE	USA	Nursing Research	001	1	6/15/2018	NEW	-$3
														Subtotal = -$3

Issue Date FY: 2016 ( Subtotal = $224,950 )
2016	2016	AXON MEDICAL, INC	3300 S 3090 Ste 3b	Salt Lake City	UT	84109	SALT LAKE	USA	Nursing Research	000	1	8/16/2016	NEW	$224,950
														Subtotal = $224,950

Grand Total All Awards = $224,947

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Detecting Drug-Induced Hypoventilation and Verbally Prompting for Patient Self-Rescue

Award Number: R43NR015955

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/16/2016

PERIOD OF PERFORMANCE END DATE: 01/31/2018

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