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Development of a Revolutionary MRI System for Functional Brain Imaging

Award Number: R43MH119021
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2018
PERIOD OF PERFORMANCE END DATE: 07/31/2019

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Development of a Revolutionary MRI System for Functional Brain Imaging - Project Summary/Abstract It is the dream of researcher's and clinician's to have available a low cost, portable MRI scanner for brain neuroimaging. However, such a low cost MRI system requires a small bore MRI magnet. Unfortunately, in the case of conventional MRI systems, small bore magnets have a usable homogeneous magnetic field Diameter Spherical Volume (DSV) that is much smaller than the size of the human brain. A new MRI approach is required to achieve the dream of a low cost portable MRI brain scanner. The general methodology used to obtain MR images today is essentially the same as that used approximately 40 years ago. In the NIH Brain Initiative funded project NIH R24 MH105998-01 - in which University of Minnesota (CMMR) is the PI, and Wang NMR, Yale University and Harvard University are key participants. - we have successfully demonstrated the feasibility of a revolutionary new MRI imaging method called STEREO which stands for STEering REsonance over the Object. By generating MRI imaging with spatiotemporal encoding, STEREO allows the Bo field to vary by amounts as large as 200 kHz or +/- 1500 ppm Bpk-pk. Therefore, STEREO for the first time, makes it possible for a much smaller bore MRI magnet, with an inherently less homogeneous magnet field, to permit good MRI imaging. In addition, it is possible to observe brain activity with zero echo time by using the SWIFT imaging technique. Using SWIFT, it is possible to transmit FM pulses and simultaneous receive signals making MRI neuroimaging an extremely inhomogeneous magnet possible. This SBIR proposal intends to exploit the unique imaging technologies demonstrated in our previous NIH funded project and to build a low cost, commercially viable MRI system with a small, light weight (250 lb.) magnet with a small bore as small as 34 cm in diameter X 34 cm long (dimensions that are 3 times smaller than traditional neuroimaging MRI magnets). The magnet will employ the lowest cost superconductor NbTi, and will be conduction cooled be a small cryo-cooler. There will be no nitrogen and helium required at all. Therefore it can be operated in any country so long as there is electricity. The magnet will be combined with a new, low cost, dynamic multi-coil gradient shimming system for Bo field modulation and with a low cost, low power (50 W) compact simultaneous transmit and receive RF spectrometer system. Successful completion of this SBIR project will demonstrate a revolutionary, portable, low cost, commercially viable MRI system for brain neuroimaging. We expect to see in the near future such brain imaging systems available for use everywhere, and to permit the imaging of brain function in all populations and environments worldwide.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$2,994 )
2022	2018	WANG NMR INC.	550 N CANYONS PKWY	LIVERMORE	CA	94551	ALAMEDA	USA	Mental Health Research Grants	000	1	6/29/2022	NEW	-$2,994
														Subtotal = -$2,994

Issue Date FY: 2018 ( Subtotal = $149,994 )
2018	2018	WANG NMR INC.	550 N CANYONS PKWY	LIVERMORE	CA	94551	ALAMEDA	USA	Mental Health Research Grants	000	1	7/27/2018	NEW	$149,994
2018	2018	WANG NMR INC.	550 N CANYONS PKWY	LIVERMORE	CA	94551	ALAMEDA	USA	Mental Health Research Grants	001	1	9/6/2018	NEW	$0
														Subtotal = $149,994

Grand Total All Awards = $147,000

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Development of a Revolutionary MRI System for Functional Brain Imaging

Award Number: R43MH119021

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2018

PERIOD OF PERFORMANCE END DATE: 07/31/2019

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