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Spatial Genomics for in situ single cell expression analysis in the brain

Award Number: R43MH115538
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2018
PERIOD OF PERFORMANCE END DATE: 12/31/2020

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Spatial Genomics for in situ single cell expression analysis in the brain - Summary Identifying the spatial organization of tissues at cellular resolution from single cell gene expression profiles is essential to understanding neurological systems. We have developed a spatial genomics approach that allows in situ 3D multiplexed imaging of many genes in single cells called sequential Fluorescence in situ hybridization (seqFISH). This technology can profile transcriptional states of single cells directly in their native tissue context with up to 249 genes multiplexed with single molecule sensitivity on each gene. We have demonstrated over 15,000 cells profiled in mouse brain slices. This SBIR project will be focused on the design, production and optimization of an instrument that allows hundreds of genes to be multiplexed and imaged in single cells within their native tissue context. The resulting machine will be commercially launched and targeted to imaging or sequencing cores at research institutions. We will design the hardware, code the control software, and build the prototype instrument. We will engineer the hardware component including automated fluidics and multiple camera imaging system with a parallel effort to develop software controls as well as integrated analysis tools. In phase II, we will beta-test the instrument, generate probe sets for gene panels targeting different brain samples, and receive valuable feedback from users and optimize our instrument design.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	SPATIAL GENOMICS, INC.	1224 E GREEN ST #120	PASADENA	CA	91106	LOS ANGELES	USA	Mental Health Research Grants	000	2	12/7/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $265,936 )
2019	2019	SPATIAL GENOMICS, INC.	1224 E GREEN ST #120	PASADENA	CA	91106	LOS ANGELES	USA	Mental Health Research Grants	000	2	6/21/2019	NON-COMPETING CONTINUATION	$265,936
														Subtotal = $265,936

Issue Date FY: 2018 ( Subtotal = $915,468 )
2018	2018	SPATIAL GENOMICS, INC.	2552 SAN PASQUAL ST	PASADENA	CA	91107	LOS ANGELES	USA	Mental Health Research Grants	001	1	8/23/2018	SUPPLEMENT FOR EXPANSION	$30,000
2018	2018	SPATIAL GENOMICS, INC.	2552 SAN PASQUAL ST	PASADENA	CA	91107	LOS ANGELES	USA	Mental Health Research Grants	000	1	6/22/2018	NEW	$885,468
														Subtotal = $915,468

Grand Total All Awards = $1,181,404

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Spatial Genomics for in situ single cell expression analysis in the brain

Award Number: R43MH115538

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2018

PERIOD OF PERFORMANCE END DATE: 12/31/2020

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