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Plasticity-based Adaptive Cognitive Remediation program (PACR) for the treatment

Award Number: R43MH101917
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/11/2013
PERIOD OF PERFORMANCE END DATE: 08/31/2016

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Plasticity-based Adaptive Cognitive Remediation program (PACR) for the treatment - DESCRIPTION (provided by applicant): The goal of the current project is to elaborate upon, reconstruct and advance to pivotal trial readiness a recently validated Plasticity-based Adaptive Cognitive Remediation program (PACR) for the treatment of HIV-Associated Neurocognitive Disorders (HAND). In the first specific aim, we will organize a series of small focus groups composed of people with HAND to discuss and play various computer games and cognitive training programs. Based on questionnaires from and discussions with these focus groups, we will define a set of enhancements to PACR designed to make the user experience and the gameplay sufficient to motivate the thirty hours of program. We will then employ established methods of software design and development and iteratively refine the implemented design to complete the development of the enhanced program for a feasibility trial conducted locally, in collaboration with the San Francisco Aids Foundation. At the completion of this project we will have data sufficient to propose a multi-site, randomized, controlled medical-device trial designed to establish medical claims defining the efficacy of this cognitive training program. At the completion of Phase II, we expect to be able to complete the FDA regulatory pathway, and clear the program as the first software based medical device intended for the treatment of HAND, and have the opportunity to improve the lives of millions of people suffering from this condition.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2014	BRAIN PLASTICITY INC.	160 PINE ST STE 200	SAN FRANCISCO	CA	94111	SAN FRANCISCO	USA	Mental Health Research Grants	000	2	1/12/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2014	POSIT SCIENCE CORPORATION	114 SANSOME STREET	SAN FRANCISCO	CA	94104	SAN FRANCISCO	USA	Mental Health Research Grants	000	2	12/18/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $324,367 )
2014	2014	POSIT SCIENCE CORPORATION	225 Bush St FL 7	San Francisco	CA	94104	SAN FRANCISCO	USA	Mental Health Research Grants	000	2	9/12/2014	NON-COMPETING CONTINUATION	$324,367
														Subtotal = $324,367

Issue Date FY: 2013 ( Subtotal = $401,310 )
2013	2013	POSIT SCIENCE CORPORATION	225 Bush St FL 7	San Francisco	CA	94104	SAN FRANCISCO	USA	Mental Health Research Grants	000	1	9/11/2013	NEW	$401,310
														Subtotal = $401,310

Grand Total All Awards = $725,677

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Plasticity-based Adaptive Cognitive Remediation program (PACR) for the treatment

Award Number: R43MH101917

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/11/2013

PERIOD OF PERFORMANCE END DATE: 08/31/2016

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