Saturday, August 2, 2025 8/2/2025

A DISPOSABLE AMPEROMETRIC LITHIUM ION-SELECTIVE ELECTRODE FOR HOME TESTING

Award Number: R43MH090779
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2009
PERIOD OF PERFORMANCE END DATE: 03/29/2011

Group Awards By:

View Award Description

A DISPOSABLE AMPEROMETRIC LITHIUM ION-SELECTIVE ELECTRODE FOR HOME TESTING - Summary There is a narrow therapeutic range associated with the use of lithium which translates to the need for routine patient monitoring to maintain the proper levels of lithium. The current monitoring methods are not amenable to home use by a patient. This translates to an increasing need to provide patients with a reliable home-based testing tool for obtaining lithium ion levels so that they can conveniently and effectively monitor and manage their care. Testing lithium ion concentration in blood is extremely challenging due to the interference from sodium ions. This research program will overcome this problem and produce a prototypical device for lithium testing through the application of three coordinated strategies. Strategy 1 is to develop amperometry-type ion-selective electrodes and use the applied potentials to tune the selectivity. Strategy 2 is to develop 14-crown-4 derivatives with a high selectivity against sodium ions. Strategy 3 is to simultaneously measure lithium and sodium ion concentrations in a single test and correct the lithium concentration with the sodium measurement. An innovative research plan for integrating these strategies into a disposable single-use electrochemical test strip is deschbed, including measurement concept, method development, ionophore selection and synthesis, electrode design and fabrication protocols. Project Narrative: This research program will produce an amperometric ion-selective electrode based device for home-based blood lithium testing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = $0 )
2011	2009	ADA TECHNOLOGIES, INC	8100 SHAFFER PARKWAY, STE 130	LITTLETON	CO	80127	JEFFERSON	USA	Mental Health Research Grants	000	1	5/3/2011	NEW	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2009	ADA TECHNOLOGIES, INC	8100 SHAFFER PARKWAY, STE 130	LITTLETON	CO	80127	JEFFERSON	USA	Mental Health Research Grants	000	1	12/3/2009	NEW	$0
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $189,886 )
2009	2009	ADA TECHNOLOGIES, INC	8100 SHAFFER PARKWAY, STE 130	LITTLETON	CO	80127	JEFFERSON	USA	Mental Health Research Grants	000	1	9/22/2009	NEW	$189,886
														Subtotal = $189,886

Grand Total All Awards = $189,886

Top

All Categories

About

Search

Reports

Data Submission

Award Information

A DISPOSABLE AMPEROMETRIC LITHIUM ION-SELECTIVE ELECTRODE FOR HOME TESTING

Award Number: R43MH090779

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2009

PERIOD OF PERFORMANCE END DATE: 03/29/2011

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer