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IN VIVO EVALUATION OF A NEW LIGAND WITH PICOMOLAR AFFINITY FOR THE SEROTONIN TRAN

Award Number: R43MH079568
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2008
PERIOD OF PERFORMANCE END DATE: 11/30/2010

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IN VIVO EVALUATION OF A NEW LIGAND WITH PICOMOLAR AFFINITY FOR THE SEROTONIN TRAN - DESCRIPTION (provided by applicant): The goal of this research project is to validate in humans a new ligand with picomolar affinity for the serotonin transporter. It will permit quantitative measurement of serotonin transporter (5- HTT) sites in living brain by imaging with single photon emission tomography (SPECT). The serotonin transporter is known to play a critical role in several physiological and pathophysiological processes, including depression, anxiety, seasonal affective disorder, bulimia, and psychosis, as demonstrated by post-mortem data, clinical efficacy of therapies affecting this target site, and imaging studies. A radiotracer that binds specifically to 5-HTT is of great utility in diagnosis, monitoring treatment, and research of these disorders. There is a need for better tracers that allow quantitation in areas of the brain with low 5-HTT densities such as the cortex.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $250,000 )
2009	2009	MOLECULAR NEUROIMAGING LLC	60 TEMPLE STREET	NEW HAVEN	CT	06510	SOUTH CENTRAL CT	USA	Mental Health Research Grants	000	2	2/18/2009	NON-COMPETING CONTINUATION	$250,000
														Subtotal = $250,000

Issue Date FY: 2008 ( Subtotal = $250,000 )
2008	2008	MOLECULAR NEUROIMAGING LLC	60 TEMPLE STREET	NEW HAVEN	CT	06510	SOUTH CENTRAL CT	USA	Mental Health Research Grants	000	1	12/28/2007	NEW	$250,000
														Subtotal = $250,000

Grand Total All Awards = $500,000

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IN VIVO EVALUATION OF A NEW LIGAND WITH PICOMOLAR AFFINITY FOR THE SEROTONIN TRAN

Award Number: R43MH079568

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2008

PERIOD OF PERFORMANCE END DATE: 11/30/2010

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