Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

BUILDING AND TESTING MULTI-LAYERED FULLY BIOLOGICAL BLOOD VESSEL SUBSTITUTES

Award Number: R43HL095191
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2009
PERIOD OF PERFORMANCE END DATE: 03/31/2010

Group Awards By:

View Award Description

BUILDING AND TESTING MULTI-LAYERED FULLY BIOLOGICAL BLOOD VESSEL SUBSTITUTES - DESCRIPTION (provided by applicant): Given the growing need for replacement tissues, organs and grafts tissue engineering has emerged as a viable regenerative/reconstructive technology. Recent spectacular results in the field suggest that it is possible to fabricate functional organ modules under laboratory conditions. The present application introduces a versatile, novel approach to engineer fully biological tissue constructs. Present efforts are focused primarily on building tubular modules. Here we detail our Phase I program with the principal objective to construct suturable, small diameter blood vessel substitutes, a critical domain within vascular medicine. Whereas synthetic materials have been successful for large diameter high flow grafts, these fail in the intermediate and small diameter sizes due to thrombogenicity and compliance mismatch. Limitations of presently used strategies to engineer small diameter conduits resulted in grafts with mechanical properties inferior to those of native blood vessels. To overcome the limitations of the classical approach we have implemented a patent-pending "print-based" tissue engineering technology. The technology on one hand relies on established principles of biological shape formation (i.e. morphogenesis), such as tissue fusion and cell sorting. On the other hand it utilizes engineering methods to speed up the process and make it reliable, thus rendering it commercially viable. The principal objective will be pursued through two specific aims. The first is to fabricate perfusable conduits and to condition them in bioreactors. The second aim is to measure the biomechanical properties (i.e. suture retention strength, burst pressure and compliance) of the conditioned conduits over time. A milestone will be to achieve physiologically relevant biomechanical properties, necessary for implantation. PUBLIC HEALTH RELEVANCE: The objective of this proposal is to construct fully biological small diameter blood vessel substitutes by a novel and versatile tissue engineering technology, and assess their biomechanical properties and structure. The proposed studies could lead to nearly physiological and implantable blood vessels composed of the patient's own cells (i.e. autologous).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $142,511 )
2009	2009	ORGANOVO INC	11996 DARLINGTON AVENUE	LOS ANGELES	CA	90049	LOS ANGELES	USA	Cardiovascular Diseases Research	000	1	8/27/2009	NEW	$142,511
														Subtotal = $142,511

Grand Total All Awards = $142,511

Top

All Categories

About

Search

Reports

Data Submission

Award Information

BUILDING AND TESTING MULTI-LAYERED FULLY BIOLOGICAL BLOOD VESSEL SUBSTITUTES

Award Number: R43HL095191

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2009

PERIOD OF PERFORMANCE END DATE: 03/31/2010

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer