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LC-BASED NITRIC OXIDE BREATH MONITOR FOR ASTHMA MANAGEMENT

Award Number: R43HL095167
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2009
PERIOD OF PERFORMANCE END DATE: 02/28/2011

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LC-BASED NITRIC OXIDE BREATH MONITOR FOR ASTHMA MANAGEMENT - DESCRIPTION (provided by applicant): The goal of this project is to develop a liquid crystal-based sensor that can detect and measure nitric oxide in exhaled breath. The sensor technology is based on a broadly applicable detection platform that exploits the sensitivity of liquid crystals (LCs) to the nanoscopic changes in the structure of surfaces. Many attributes of this LC technology suggest that it offers exciting potential for clinical applications. It can be used to fabricate low cost, highly specific sensor elements that analyze chemicals in real time (response in ~ 10 seconds), are highly sensitive (can detect 1 ppb or less in vapor phase), provide a wide dynamic range (4 orders of magnitude), offer format flexibility, and are easily customized to detect selected compounds. Because the technology does not require expensive or complex instrumentation, or highly skilled personnel to operate the equipment, it is ideally suited as a cost-effective and reliable approach for breath monitoring. The outcome of this Phase I proposal will be a sensor element that can detect and measure ppb levels of exhaled nitric oxide. The LC-based sensor elements are small (<1cm in size) and will be integrated with electronics to analyze and report analyte concentrations. Our intended product will display a readout of the collected data to the user. Such a product will enable self- monitoring by asthmatics and play a key role in disease management. PUBLIC HEALTH RELEVANCE: The goal of this project is to develop a liquid crystal-based sensor that can detect and measure nitric oxide in exhaled breath. The sensor technology is based on a broadly applicable detection platform that exploits the sensitivity of liquid crystals (LCs) to the nanoscopic changes in the structure of surfaces. Many attributes of this LC technology suggest that it offers exciting potential for clinical applications. It can be used to fabricate low cost, highly specific sensor elements that analyze chemicals in real time (response in ~ 10 seconds), are highly sensitive (can detect 1 ppb or less in vapor phase), provide a wide dynamic range (4 orders of magnitude), offer format flexibility, and are easily customized to detect selected compounds. Because the technology does not require expensive or complex instrumentation, or highly skilled personnel to operate the equipment, it is ideally suited as a cost-effective and reliable approach for breath monitoring. The outcome of this Phase I proposal will be a sensor element that can detect and measure ppb levels of exhaled nitric oxide. The LC-based sensor elements are small (<1cm in size) and will be integrated with electronics to analyze and report analyte concentrations. Our intended product will display a readout of the collected data to the user. Such a product will enable self- monitoring by asthmatics and play a key role in disease management.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $199,987 )
2010	2010	PLATYPUS TECHNOLOGICS LLC	5520 NOBEL DRIVE SUITE 100	MADISON	WI	53711	DANE	USA	Lung Diseases Research	000	2	2/16/2010	NON-COMPETING CONTINUATION	$199,987
														Subtotal = $199,987

Issue Date FY: 2009 ( Subtotal = $199,952 )
2009	2009	PLATYPUS TECHNOLOGICS LLC	5520 NOBEL DRIVE SUITE 100	MADISON	WI	53711	DANE	USA	Lung Diseases Research	000	1	2/20/2009	NEW	$199,952
														Subtotal = $199,952

Grand Total All Awards = $399,939

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LC-BASED NITRIC OXIDE BREATH MONITOR FOR ASTHMA MANAGEMENT

Award Number: R43HL095167

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2009

PERIOD OF PERFORMANCE END DATE: 02/28/2011

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