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INFECTION RESISTENT COATINGS FOR MECHANICAL CIRCULATORY SUPPORT SYSTEMS (MCSS)

Award Number: R43HL092637
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/02/2009
PERIOD OF PERFORMANCE END DATE: 01/31/2010

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INFECTION RESISTENT COATINGS FOR MECHANICAL CIRCULATORY SUPPORT SYSTEMS (MCSS) - DESCRIPTION (provided by applicant): The high risk of infection posed by the use of paracorporeal and implanted mechanical circulatory support systems (MCSS) continues to create significant clinical complications. In this Phase I proposal, Ension will develop and assess the feasibility of a biointegrative surface coating that can be applied to implantable devices, cannulae, and drivelines. The proposed surface modification will consist of a surface layer formulated to prevent bacterial adhesion and a grafted near natural layer of collagen that will favor a normal healing response over the formation of a thick, fibrous capsule that can compromise immune function. In addition, the proposed engineered surface will be amenable to incorporating an antimicrobial that will release in a controlled manner over time. The goal of the proposed Phase I SBIR is to develop and demonstrate the feasibility of an infection resistant surface with the aim of reducing infection related complications of mechanical circulatory support. PUBLIC HEALTH RELEVANCE: The product of this research, an infection resistant surface coating, has application to any medical apparatus that passes through human skin at risk for infection. This includes the surfaces and transcutaneous component of artificial organs, cannula, fistula, and catheters.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $157,723 )
2009	2009	ENSION, INC	240 WILLIAM PITT WAY	PITTSBURGH	PA	15238	ALLEGHENY	USA	Cardiovascular Diseases Research	000	1	1/30/2009	NEW	$157,723
														Subtotal = $157,723

Grand Total All Awards = $157,723

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INFECTION RESISTENT COATINGS FOR MECHANICAL CIRCULATORY SUPPORT SYSTEMS (MCSS)

Award Number: R43HL092637

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/02/2009

PERIOD OF PERFORMANCE END DATE: 01/31/2010

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