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OPTICAL TOMOGRAPHY FOR CARDIAC IMAGING OF SMALL ANIMALS

Award Number: R43HL075959
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2004
PERIOD OF PERFORMANCE END DATE: 07/31/2004

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OPTICAL TOMOGRAPHY FOR CARDIAC IMAGING OF SMALL ANIMALS - DESCRIPTION (provided by applicant): We propose to develop a thermoacoustic-imaging device capable of making axial images of the cardiac anatomy in small animals such as mice and rats using near infrared light. The device we envision will allow researchers to assess cardiac dynamics and to study transgenic models of cardiovascular disease, such as cardiac hypertrophy and atherosclerosis. Ultimately we plan to develop a device capable of forming high-resolution images at a frame rate of 100 - 200 Hz, sufficient to image the cardiac dynamics of mice and rats. One advantage offered by such a device is that cardiac dynamics can be studied without the need for injecting vascular-enhancing contrast material. In Phase I, we will design, construct and test a focused, circular transducer array capable of collecting sufficient thermoacoustic data to reconstruct a 1-mm-thick axial slice following a single, 10-ns pulse of near infrared laser light. Because the laser pulse is so short, we should encounter virtually no blur due to heart-wall motion when imaging live animals. We hope to achieve in-plane spatial resolution of < 200 microns. Due to limitations of our present digital acquisition system (DAS), we will only have the capability of forming images at 2 frames per second during Phase I. In Phase II we will demonstrate our ability to form dynamic image sequences of the heart in mice and rats. To this end we will redesign our DAS to allow us to acquire dynamic image sequences at rates as high as 200 Hz. We will also incorporate a custom-designed, tunable, near-infrared laser capable of pulsing at 200 Hz. In this phase we will develop multi-slice imaging protocols to form 3-D images of the beating heart.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $111,165 )
2004	2004	OPTOSONICS, INC	7534 NOEL ROAD	INDIANAPOLIS	IN	46278	MARION	USA	Cardiovascular Diseases Research	000	1	1/26/2004	NEW	$111,165
														Subtotal = $111,165

Grand Total All Awards = $111,165

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OPTICAL TOMOGRAPHY FOR CARDIAC IMAGING OF SMALL ANIMALS

Award Number: R43HL075959

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2004

PERIOD OF PERFORMANCE END DATE: 07/31/2004

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