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A quick, and robust, and unbiased platform for circular RNAs isolation, discovery and profiling.

Award Number: R43HG013073
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/09/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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A quick, and robust, and unbiased platform for circular RNAs isolation, discovery and profiling. - The goal of this proposal is to develop and validate a novel platform for the enrichment of the complete repertoire of circular RNAs (circRNAs). Thousands of circRNAs have been reported since their discovery >40 years ago from human transcriptome. The importance of circRNAs can be gauged from the fact that they are broadly expressed in eukaryotic cells, show cell and tissue-type specificity; and their expression is often conserved across species. CircRNAs have been implicated in neurological diseases, innate immunity, hepatocellular carcinoma and lung fibrosis demonstrating their role in cellular physiological and pathological pathways. The present approaches are reported to be biased in enriching circRNAs repertoire. Given their importance in various diseases, there is an urgent and unmet need for efficient circRNA isolation technology. In Phase-I application, we proposed two specific aims to develop Quick-circRNA platform, validate and compare its efficacy with current methods. In aim-1 we will develop and establish Quick-circRNA platform in various conditions and cell types in obtaining uniform an unbiased enrichment of circRNAs. In aim-2 we will compare the efficacy of Quick-circRNA with known methods in various cellular conditions. We believe that phase-I proposal will provide a benchmark for phase-II, which can streamline the Quick-circRNA platform for enriching circRNAs with high reproducibility and efficiency. In the end, we will develop a quick, and robust, and unbiased platform for circular RNAs isolation, discovery and profiling.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	RIBO-THERAPEUTICS LLC	6076 CORTE DEL CEDRO	CARLSBAD	CA	92011	SAN DIEGO	USA	Human Genome Research	000	1	5/12/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $352,929 )
2023	2023	RIBO-THERAPEUTICS LLC	6076 CORTE DEL CEDRO	CARLSBAD	CA	92011	SAN DIEGO	USA	Human Genome Research	000	1	8/9/2023	NEW	$352,929
														Subtotal = $352,929

Grand Total All Awards = $352,929

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A quick, and robust, and unbiased platform for circular RNAs isolation, discovery and profiling.

Award Number: R43HG013073

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/09/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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