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Link phenotypic characteristics with gene expression profile of single cells at high throughput for drug discovery and cell therapy development

Award Number: R43HG012528
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2022
PERIOD OF PERFORMANCE END DATE: 02/14/2024

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Link phenotypic characteristics with gene expression profile of single cells at high throughput for drug discovery and cell therapy development - PROJECT SUMMARY / ABSTRACT Researchers have shown substantial interest in the integration of phenomics and transcriptomics data for novel biological insights since phenotypic characteristics are highly correlated with gene expression patterns. However, there is a lack of an efficient approach that could link gene expression profiles to cellular phenotypes (e.g., protein abundance and localization, cellular morphology, enzymatic and metabolic activity) at single-cell level in a high-throughput manner. To bridge this gap, WellSIM proposes to develop a platform which can extract phenotypic characteristics from thousands of individual cells via high-content imaging and link these features with their transcriptomic profiles. This technology will not only achieve multi-dimensional single cell studies, but also improve the performance of single-cell RNA sequencing through automatic sample preparation on a microfluidic device without using barcoded beads.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	WELLSIM BIOMEDICAL TECHNOLOGIES INC	160 E TASMAN DR	SAN JOSE	CA	95134	SANTA CLARA	USA	Human Genome Research	000	1	7/1/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $246,812 )
2022	2022	WELLSIM BIOMEDICAL TECHNOLOGIES, INC.	930 CORAL RIDGE CIR	RODEO	CA	94572	CONTRA COSTA	USA	Human Genome Research	000	1	8/12/2022	NEW	$246,812
														Subtotal = $246,812

Grand Total All Awards = $246,812

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Link phenotypic characteristics with gene expression profile of single cells at high throughput for drug discovery and cell therapy development

Award Number: R43HG012528

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2022

PERIOD OF PERFORMANCE END DATE: 02/14/2024

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