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A Unique Body-Powered Terminal Device with Enhanced Grasping Capabilities for Individuals with Upper Limb Loss

Award Number: R43HD115423
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2025
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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A Unique Body-Powered Terminal Device with Enhanced Grasping Capabilities for Individuals with Upper Limb Loss - PROJECT SUMMARY Objective Our objective is to develop and test a novel body-powered prosthetic terminal device. The device is the first of its kind to exhibit both high and low grasp forces while still exhibiting exceptional strength and durability. Significance Upper limb prosthesis disuse and abandonment rates are alarmingly high, and individuals with upper limb loss indicate that they would use prostheses if they exhibited improved functionality. Namely, there is a need for a body-powered terminal device that displays excellent durability (allowing for push/pull tasks) as well as enhanced gripping and grasping capabilities. The need for such work is captured in the results of our recent survey of individuals with upper limb loss. The perspective of one such individual is captured in this quote: A lot of emphasis continues to be placed on R&D for external powered solutions to upper extremity prostheses. Body powered prostheses and activity specific prostheses R&D get almost no support. Both technologies should be developed and researched...not just bionic technology…Pursue the research but balance the research with also a pursuit of improving other more basic and more functional, less expensive reliable technologies. Innovation The Adaptive Grasp Force (AGF) terminal device is a body-powered device with excellent strength and durability. Unlike commercially available body-powered devices, however, the AGF device can achieve a wide range of grasp forces in a single device. This enhanced functionality is enabled by a novel mechanism which exhibits non-backdrivable behavior, allowing for improved bimanual grasping functionality. The mechanism is both low cost and highly durable (due to surface contact mechanics), facilitating rapid clinical adoption. Approach We intend to continue development of the AGF terminal device in order to test it in a series of functional assessments relative to a commercially available body-powered device. We propose 3 specific aims: 1) develop and fabricate the AGF device, 2) assess the device with able-bodied users in series of functional assessments, and 3) perform durability and accelerated lifetime testing on the AGF device. This approach is carefully designed to de-risk the AGF device from both a mechanical design and clinical impact perspective. If the proposed aims are successful, we will continue development towards full clinical deployment in a Phase II effort. In that effort, we plan to 1) redesign the AGF device based on lessons learned during Phase I, 2) conduct controlled clinical assessments of the terminal device with upper limb prosthesis users, and 3) conduct a take-home assessment of the device to examine its utility in real-world scenarios.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	LITTLE ROOM INNOVATIONS LLC	2560 PRAIRIE ST	ANN ARBOR	MI	48105	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	1	12/19/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $304,906 )
2025	2025	LITTLE ROOM INNOVATIONS LLC	2560 PRAIRIE ST	ANN ARBOR	MI	48105	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	1	6/16/2025	NEW	$304,906
														Subtotal = $304,906

Grand Total All Awards = $304,906

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A Unique Body-Powered Terminal Device with Enhanced Grasping Capabilities for Individuals with Upper Limb Loss

Award Number: R43HD115423

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2025

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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