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Addressing Gaps in Pediatric Prescribing Using Scalable and Interoperable Prescription Decision Support

Award Number: R43HD093501
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/08/2017
PERIOD OF PERFORMANCE END DATE: 03/07/2019

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Addressing Gaps in Pediatric Prescribing Using Scalable and Interoperable Prescription Decision Support - ABSTRACT Significance: Electronic-prescribing is now widely adopted by US healthcare systems, but clinical functionality of e-prescribing falls short in the realm of pediatrics. Medication prescribing is intrinsically more complex for pediatric patients due to weight-based dosing, the lack of widely adopted medication formulation recipes, inconsistent off-label usage of drugs, appropriate drugs for given conditions, and appropriate dose rounding percentages that will still make the drug treatment clinically useful. Clinical decision support (CDS) tools can improve shortcomings in electronic health records (EHR), yet many focus on adult only patient populations, are limited in drug and condition coverage, exist as web-services external to the native EHR environment, and generate excessive pop-up alerts that contribute to provider “alert-fatigue”. Safety Through E-Prescribing Systems Tools (STEPSTools) is a web-service that was designed to be a comprehensive pediatric dosing knowledge dissemination platform that fills the void of condition based medication usage, expert consensus- based dosage rounding, and extemporaneous drug formulation recipes currently missing in EHR functionality. RxCheck is a Prescription Decision Support (PDS) platform built by RxREVU, that is surfaced directly in the provider’s native Epic EHR workflow to ensure the accuracy of information utilization by providers, drive operational best practices, surface information that may or may not natively exist in the EHR, and improve the clinical window. Hypothesis: By combining the strengths and expertise of STEPSTools pediatric prescribing technology with RxREVU’s RxCheck Prescription Decision Support platform, a comprehensive pediatric prescribing product will be developed that is scalable, interoperable, and utilized directly at the point of prescribing in order to drive consistent evidence-based prescribing patterns for pediatricians, and improve clinical outcomes for pediatric patients. Specific Aims: By the investigators own admission, a pediatric prescribing technology will not be useful if it is not comprehensive and up-to-date. This proposal aims to update STEPSTools technology from 2011 pediatric prescribing standards to 2016 standards, as new evidence and innovative approaches to pediatric prescribing have occurred. Rapid and effective communication between STEPSTools, RxCheck and Vanderbilt’s Epic EHR is critical for the accuracy and safety of the prescribing module. These data handshakes will be rigorously tested for accuracy in the second aim. Provider adoption and clinical utility of an RxCheck pediatric prescribing module is critical to test the feasibility of widespread scalability of the tool. The number of times RxCheck is accessed compared to total prescriptions written, as well as provider acceptance rates of the recommendations surfaced by RxCheck in Epic will be measured and success of this Phase I SBIR proposal will be determined here.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	RXREVU, INC.	1553 PLATTE ST STE 202	DENVER	CO	80202	DENVER	USA	Child Health and Human Development Extramural Research	000	1	11/8/2019	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $149,629 )
2017	2017	RXREVU, INC.	1553 PLATTE ST STE 202	DENVER	CO	80202	DENVER	USA	Child Health and Human Development Extramural Research	000	1	9/8/2017	NEW	$149,629
														Subtotal = $149,629

Grand Total All Awards = $149,629

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Addressing Gaps in Pediatric Prescribing Using Scalable and Interoperable Prescription Decision Support

Award Number: R43HD093501

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/08/2017

PERIOD OF PERFORMANCE END DATE: 03/07/2019

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