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A NEW OCULAR NEOVASCULARIZATION MODEL

Award Number: R43EY016916
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2005
PERIOD OF PERFORMANCE END DATE: 08/31/2006

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A NEW OCULAR NEOVASCULARIZATION MODEL - DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are the two leading causes of blindness in adults in the industrialized world. Retinopathy of prematurity (ROP) is a major cause of newborn blindness in premature infants maintained by oxygen supplementation during the postnatal period. In each of these diseases, ischemia resulting from loss of blood flow induces pathological neovascularization in the eye. There are several animal models of eye neovascularization (e.g. the corneal pocket assay); however, drug screening using these models is time-consuming, requires complicated surgery, and can be done in only a few animals. In addition, the complexity of eye neovascularization related diseases necessitates the development of new animal models for therapeutic drug assessment. This SBIR aims to develop a quantitative in vivo zebrafish neovascularization animal model for screening drugs for human eye diseases. The conserved early development of zebrafish and human eye vasculature supports the zebrafish as a model for studying vascular diseases affecting the eye. In addition to developmental progression, angiogenesis and vasculogenesis are conserved between zebrafish and mammals at the molecular level.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $173,516 )
2005	2005	PHYLONIX PHARMACEUTICALS, INC	100 INMAN STREET SUITE 300	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Vision Research	000	1	9/16/2005	NEW	$173,516
														Subtotal = $173,516

Grand Total All Awards = $173,516

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A NEW OCULAR NEOVASCULARIZATION MODEL

Award Number: R43EY016916

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2005

PERIOD OF PERFORMANCE END DATE: 08/31/2006

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