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IRaman: Breakthrough biomedical microscope with simultaneous infrared and Raman spectroscopy at sub-micron spatial resolution

Award Number: R43EB027018
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2018
PERIOD OF PERFORMANCE END DATE: 08/31/2019

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IRaman: Breakthrough biomedical microscope with simultaneous infrared and Raman spectroscopy at sub-micron spatial resolution - Anasys Instruments proposes to develop an optical platform that combines confocal Raman spectroscopy with infrared spectroscopy with sub-micron spatial resolution on a single optical microscope based platform (patents pending). Infrared spectroscopy and Raman spectroscopy are separately extremely successful and complementary techniques for chemical composition analysis. Infrared spectroscopy characterizes samples by detecting absorption of infrared light by dipole moment changes induced in molecular bond vibrations. Raman spectroscopy detects scattered light that wavelength shifted by a sample due to molecular vibrations that induce changes in polarizability. The techniques are highly complementary because molecular vibrations that are strong IR absorbers are typically weak Raman scatterers and vice versa. Conventional IR spectroscopy has two significant limit fundamental limitations: (1) spatial resolution limited by optical diffraction from its longer wavelengths to the scale of many microns; (2) sample preparation is often complex, requiring preparation of thin IR transparent samples. These limitation, along with sample preparation complexities have limited applicability of IR spectroscopy in many life sciences applications. Differences in IR and Raman wavelength ranges, light sources and detectors have also made it impossible to obtain IR and Raman spectroscopy from the same sample region. As a result, there is no currently available instrument that can perform infrared and Raman analysis on the same sample with sub-micron spatial resolution for both techniques. We propose to overcome this limitation developing and demonstrating the applicability of the IRaman platform which will provide simultaneous and complementary IR and Raman analysis in the same instrument. This project will leverage the recent invention of sub-micron photothermal IR spectroscopy, a technique that uses a tightly focused visible laser to probe the infrared absorption on a scale ~10X smaller than the IR optical diffraction limit. Complementary Raman measurements will be obtained by using the same visible laser beam in combination with a Raman spectrometer to excite and detect Raman scattering in the sample. A Prototype instrument will be built to demonstrate utility of simultaneous IR/Raman technique in a couple of high value biomedical applications. Anasys has extensive experience in successful commercialization of breakthrough IR analysis products based on photothermal physics Anasys Instruments Proprietary and Confidential 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	PHOTOTHERMAL SPECTROSCOPY CORP.	325 CHAPALA ST	SANTA BARBARA	CA	93101	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	1/14/2020	NEW	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $219,286 )
2018	2018	PHOTOTHERMAL SPECTROSCOPY CORP.	325 CHAPALA ST	SANTA BARBARA	CA	93101	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/1/2018	NEW	$219,286
														Subtotal = $219,286

Grand Total All Awards = $219,286

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IRaman: Breakthrough biomedical microscope with simultaneous infrared and Raman spectroscopy at sub-micron spatial resolution

Award Number: R43EB027018

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2018

PERIOD OF PERFORMANCE END DATE: 08/31/2019

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