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Topical delivery of therapeutic aptamers

Award Number: R43EB026362
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2018
PERIOD OF PERFORMANCE END DATE: 09/29/2021

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Topical delivery of therapeutic aptamers - PROJECT ABSTRACT Topical delivery of therapeutic agents across skin offers key benefits in improving patient compliance, lowering systemic drug exposure, and enabling tunable delivery. Therapeutic macromolecules such as antibodies or aptamers enables better efficacy, less off-target effects, and longer half-life comparing to small molecules, and may unlock tremendous additional value if delivered topically. Multiple approaches have been developed for transdermal delivery of macromolecules, but have so far met with commercial and/or clinical setbacks. In consequence, so far topical delivery is critically limited to small molecules that possess particular physicochemical properties to diffuse across the skin barrier. There is a significant unmet need for a platform technology that can effectively deliver therapeutic macromolecules across the skin. Aptamers are single stranded oligonucleotides that bind to molecular targets with high potency and specificity, similar to antibodies. Comparing to antibodies, aptamers are a unique fit for topical delivery thanks to its small size, superior stability, and lack of immunogenicity. We propose to develop the first platform to effectively deliver therapeutic aptamers across the skin, and enable safer and more efficacious treatment of skin diseases. If successful, this platform has the potential to enable topical delivery of aptamers targeting many targets and disease indications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2018	APTITUDE MEDICAL SYSTEMS, INC.	125 CREMONA DR # 100	GOLETA	CA	93117	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	2/17/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	APTITUDE MEDICAL SYSTEMS, INC.	2219 BATH ST	SANTA BARBARA	CA	93105	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/23/2020	NEW	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	APTITUDE MEDICAL SYSTEMS, INC.	2219 BATH ST	SANTA BARBARA	CA	93105	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	12/18/2018	NEW	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $293,239 )
2018	2018	APTITUDE MEDICAL SYSTEMS, INC.	2219 BATH ST	SANTA BARBARA	CA	93105	SANTA BARBARA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/22/2018	NEW	$293,239
														Subtotal = $293,239

Grand Total All Awards = $293,239

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Topical delivery of therapeutic aptamers

Award Number: R43EB026362

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2018

PERIOD OF PERFORMANCE END DATE: 09/29/2021

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