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High-throughput single-cell sorting and kinetic analysis of secreted particles

Award Number: R43EB021129
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2015
PERIOD OF PERFORMANCE END DATE: 11/30/2016

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High-throughput single-cell sorting and kinetic analysis of secreted particles - ¿ DESCRIPTION (provided by applicant): Advances in reagents and analytical tools have improved characterization of cellular phenotypes. However, most studies are still performed on cell populations that are morphologically and genetically homogeneous, yet have important biological heterogeneity; with individual cells having unique phenotypic or `omic profiles. This leads to an average measurement of individual cells, none of which may actually be average. Single-cell analysis can define the scope of cell-to-cell variations within a population and provid in-depth analysis of single, exceptional cells in contexts such as stem cell differentiation or cancer, where these cells can give rise to clonal populations that drive the biology. While novel tools such as multiparameter flow cytometry, mass cytometry, and image-based cytometry provide in-depth analysis of individual cells, these technologies only provide a single time point "snapshot" and lack downstream molecular analysis. This project will develop a integrated cell-sorting and single-cell positioning device to allow single cells to be tracked and measured over time. This system will use a conventional multi-well plate format allowing the use of existing microscopy and analysis platforms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	NANOCELLECT BIOMEDICAL, INC.	7770 REGENTS RD 113390	SAN DIEGO	CA	92122	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	4/18/2017	NEW	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $224,599 )
2015	2015	NANOCELLECT BIOMEDICAL INC	7770 REGENTS ROAD	SAN DIEGO	CA	92122	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/24/2015	NEW	$224,599
														Subtotal = $224,599

Grand Total All Awards = $224,599

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High-throughput single-cell sorting and kinetic analysis of secreted particles

Award Number: R43EB021129

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2015

PERIOD OF PERFORMANCE END DATE: 11/30/2016

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