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Commercialization of a preclinical Magnetic Particle Imaging system with sub-millimeter resolution, nano-molar sensitivity, and integrated CT

Award Number: R43EB020463
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2015
PERIOD OF PERFORMANCE END DATE: 04/30/2017

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Commercialization of a preclinical Magnetic Particle Imaging system with sub-millimeter resolution, nano-molar sensitivity, and integrated CT - ¿ DESCRIPTION (provided by applicant): The two dominant preclinical molecular imaging techniques, optical imaging and nuclear imaging, have technical limitations that hamper their use in applications requiring high resolution, longitudinal tracer imaging with absolute quantitation. We are developing a new molecular imaging modality, Magnetic Particle Imaging (MPI), which does not have these limitations and is capable of: nanomolar sensitivity, absolute quantitation of a tracer, resolution independent of depth, and monitoring a stable tracer for weeks to months. These capabilities make MPI complementary to existing molecular imaging techniques and give scientists a versatile new tool when imaging cancer, tracking therapeutic and immune cells, and imaging the cardiovascular system. MPI is best compared with nuclear medicine, in that both modalities "see" only the injected tracer, both modalities can "see" right through background tissue, and both modalities are translatable. The MPI technique works by directly detecting the nonlinear magnetization of iron-oxide tracers using low-frequency magnetic fields. MPI's method of direct detection is exquisitely sensitive and we have already demonstrated nanomolar sensitivities in prototype systems. Indeed, the theoretical sensitivity limit of MPI may be as low as a single tagged cell in a voxel. MPI is unrelated to Magnetic Resonance Imaging (MRI), and MPI scans cannot be acquired using a MRI imager. This project aims to develop the first MPI system tailored for pre-clinical researchers working with mouse and rat models. The proposed system will be the world's highest sensitivity and highest resolution tomographic MPI scanner, as well as the first MPI system with integrated CT. First, we will build a high strength field free line magnetic field gradient mounted to a rotating gantry o enable tomographic MPI imaging. We will then integrate CT to enable acquisition of a tissue reference image. Last, we will test the imager on phantoms and post mortem animals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$3,167 )
2017	2016	MAGNETIC INSIGHT, INC	980 ATLANTIC AVE, SUITE 102	ALAMEDA	CA	94501	ALAMEDA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	9/27/2017	NON-COMPETING CONTINUATION	-$3,167
														Subtotal = -$3,167

Issue Date FY: 2016 ( Subtotal = $348,285 )
2016	2016	MAGNETIC INSIGHT, INC	39655 EUREKA DR	NEWARK	CA	94560	ALAMEDA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	5/18/2016	NON-COMPETING CONTINUATION	$348,285
														Subtotal = $348,285

Issue Date FY: 2015 ( Subtotal = $379,641 )
2015	2015	MAGNETIC INSIGHT, INC	39655 EUREKA DR	NEWARK	CA	94560	ALAMEDA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	8/14/2015	SUPPLEMENT FOR EXPANSION	$31,356
2015	2015	MAGNETIC INSIGHT, INC	39655 EUREKA DR	NEWARK	CA	94560	ALAMEDA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	4/24/2015	NEW	$348,285
														Subtotal = $379,641

Grand Total All Awards = $724,759

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Commercialization of a preclinical Magnetic Particle Imaging system with sub-millimeter resolution, nano-molar sensitivity, and integrated CT

Award Number: R43EB020463

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2015

PERIOD OF PERFORMANCE END DATE: 04/30/2017

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