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FAST LOW-DOSE CT DETECTOR FOR SMALL ANIMAL IMAGING

Award Number: R43EB003058
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/04/2004
PERIOD OF PERFORMANCE END DATE: 01/31/2005

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FAST LOW-DOSE CT DETECTOR FOR SMALL ANIMAL IMAGING - DESCRIPTION (provided by applicant): We will develop a fast, low-dose, direct-conversion x-ray detector for pre-clinical small animal imaging. The detector will improve micro-CT imaging of animal and specimen with fast readout, reduced dose, high throughput, and low detector cost. It can be incorporated into micro-CT systems to reduce the radiation dose delivered to animals and will enable new procedures that are not currently feasible due to the characteristics of present x-ray detectors. Micro-CT scanners have become integral to the study of disease progression and to drug development in small animals. By combining the ease of animal studies with the high resolution of small-animal CT, research is faster and at a lower cost than with conventional techniques. Manufacturers of functional imaging systems such as microPET and microSPECT (1) are also integrating micro-CT detectors into their systems for localizing functional activity anatomically, performing attenuation correction, and for enabling CT-based diagnostics. Although these systems enable longitudinal studies, multiple micro-CT scans deliver a large radiation dose to the animal, which can perturb the intended experiment or even kill the subject. The dose efficiency of current scintillator-CCD or -CMOS photodiode array x-ray detectors is compromised by inefficient conversion of x-rays to light, transport of the light to the detector, and conversion of the light to electric signal. We have successfully developed a new direct x-ray converter material, polycrystalline mercuric iodide, which is a high-Z large bandgap compound semiconductor with outstanding charge collection properties. The proposed detector is a thin film of poly-crystalline mercuric iodide for direct conversion of incident x-rays into charge, coupled to a CMOS readout structure for charge readout. Dose reduction and improved throughput will be achieved due to the very high sensitivity of mercuric iodide films. We expect to widely market the device as an OEM component to scanner manufacturers. In Phase I of the project, we will develop wafer-level processing to adapt an existing CMOS readout device for compatibility with the Hgl2 film, the film deposition techniques, and final assembly testing. In Phase II we will customize the design of the CMOS readout chip for full optimization, modify the Hgl2 deposition as required, and complete a product prototype. Phase II testing of detector prototypes will be performed at both Photon Imaging and UCSF in their new small animal CT/SPECT systems.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $165,000 )
2004	2004	PHOTON IMAGING, INC	19355 BUSINESS CTR DR SUITE 8	NORTHRIDGE	CA	91324	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	2/3/2004	NEW	$165,000
														Subtotal = $165,000

Grand Total All Awards = $165,000

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FAST LOW-DOSE CT DETECTOR FOR SMALL ANIMAL IMAGING

Award Number: R43EB003058

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/04/2004

PERIOD OF PERFORMANCE END DATE: 01/31/2005

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